Oral administration of different dosage forms is the most common form of administration due to greater patient compliance. Time-dependent drug delivery systems have been widely used for colon-targeted delivery. This study, Eudragit RS 100 was used as a Time-dependent polymer. Single pH-dependent NPs (pH-NPs), single time-dependent NPs (Time_NPs), and dual pH/time-dependent NPs (pH-NPs) were prepared using the oil-in-water emulsion method. In present study colonic drug delivery is prepared in form of nanoparticles by using oil in water or Nano precipitation method. Nanoparticles having various advantages over tablets or capsules as short gastric residence time, improved bioavailability.