The purpose of this article brings out the fabrication and recent clinical research in osmotic drug delivery system. The technology of osmotic drug delivery system need to be modified for the conventionally control over their release and almost control the safe and effective concentration in the targeted sites. The certain phenomenon of molecule may have low bioavailability hence to be improve by the fabrication osmotic drug delivery system is most promising system for controlled drug delivery system. The pump and technique most is used to developed the research point of view. The number of marketed oral osmotically driven system (OCDDS) has doubled in the last 11 years. The osmotic pressure utilized for osmotic drug delivery system (OCDDS).