American Journal of PharmTech Research AJPTR 2249-3387 undefined AJPTR75005 An Efficient One Pot Synthesis of Biologically Active Quinoline Trifluoro Esters and DNA Studies Aravinda T. Rao M.S. Raghu1and Srilatha Department of Chemistry, Nitte Meenakshi Institute of Technology, Yelahanka, Bangalore-560064, India. 10 01 2017 7 5

We deliver chemistry of multicomponent reaction (MCR) for 2-Benzyl-5-(2-benzyloxycarbonylamino-3-Phenyl-propylamino)-4-(2-chloro-quinoline-3yl)-5-(2,2,2-trifluoro acetoxy)-pentanoic acid methyl ester (6a-g) by flexible Ugi multi-component approach, through commercially available amino acid,  aldehydes, isocyanides and amino acid ester in one pot. Further, the binding activity with CT DNA and nucleus property with pUC 19 DNA were studied by absorption spectra (Kb constant is= 4.2 × 10-4 M-1). The DNA binding results explored that the new molecule bind to DNA through interaction and also an efficient nucleus agent.

 Multicomponent synthesis Ugi reaction Quinolines DNA Binding Photonuclease activity.