This study was taken up to assess the aqueous and ethanol extracts of whole plant of Potentilla anserina Linn for anti-inflammatory activity in rats by Formalin induced paw oedema method. Animals were divided into 6 groups of 6 rats. Groups 1 and 2 served as Formalin induced control and standard (Diclofenac 5 mg/Kg, i.p.) respectively. Groups 3 and 4 were treated, orally with aqueous extract of Potentilla anserina Linn of 100 and 400 mg/kg b.w, respectively. Groups 5 and 6 were administered, orally with ethanol extract of Potentilla anserina Linn of 100 and 400 mg/kg b.w, respectively. The paw volume was measured at 0, 1, 2, 3 and 4 hr after Formalin injection. The actual edema volume was calculated. The data was expressed as mean ± S.E.M. The statistical analysis was done by means of ANOVA followed by Dunnett’s post hock test. The aqueous and ethanol extracts of whole plant of Potentilla anserina Linn produced significant reduction of edema in the rats. Ethanol extract of whole plant of Potentilla anserina Linn revealed significant anti-inflammatory activity.