[NSAIDs] “non-steroidal anti-inflammatory drugs” always enter in the management  of chronic diseases associated with inflammation, but it have many unwanted side effects, one of them is stomach irritation and ulceration. The Co-drug approach is a strategy used to solve this problem. The mutual Pro-drug composed of two therapeutically active materials coupled to each other via covalent bond.  Because of the infection always lead to inflammation. So [NSAID] could be coupled with sulfa drugs together as single drug via amide linkage. Here the carrier molecules “sulfonamides” could be helpful to counteract  part of side effects of prime drug especially (GI) ulceration.  By this work I wish to explain the procedure that I used in coupling of Etodolac and Tolmetin with different sulfa drugs to create amide containing products. Therefor  the synthesized products could be useful in the management of infection and inflammations. Key words: Mutual prodrug, Etodolac, Tolmetin [NSAID], Drugs [Sulfa Drug].