This prospective interventional in-vitro study was aimed at evaluating the effect of pre-processing treatment of ridge-lap surfaces of acrylic teeth, on the strength of the bond between the teeth and the denture base resin. Three test groups included application of mono-methylmethacrylate, air-abrasion with 110-µm aluminium oxide particles and combination of the two methods. A total of 40 tooth-acrylic resin samples were equally divided into four groups (three test groups and one control group) and shear load testing was carried out in the Universal testing machine. Tukey post-hoc analysis revealed that Group IV had significantly higher mean compressive strength than Group I (*p