Cefixime, cefpodoxime and cefepime are cephalosphrin antibiotics used widely in the different infectious diseases. Newer HPTLC methods were developed for their estimation from individual dosage forms due to versatile applications and advantages. The HPTLC chromatogram of cefixime was developed by using a mobile phase ethylene acetate: methanol: water (4.5:5:0.5%v/v) and scanning wavelength was 292nm. The Rf value was 0.58±0.02. The mobile phase optimized for cepodoxime was methanol: ethyl acetate: toluene (1.5:3:5.5% v/v), with the Rf value 0.53±0.02. The cefixime was retained using methanol :water : chloroform (6:3:1%v/v), on a  silica gel G60 F254 aluminium sheet and  scanning wavelength kept at 285nm. The Rf value was 0.44. The methods were optimized validated as per guidelines and successfully applied for individual dosage form containing  of each of cephalosporin.