Talinum fruticosum.L (Talinaceae) is a erect, stout, fleshy, perennial herb. It is used as a leaf vegetable. It contain rich in vitamins including vitamin A and C and minerals such as iron and calcium. The present work highlights phytochemical and antimicrobial studies of Talinum fruticosum. The whole plant were collected from Kasaragod district and subjected to successive solvent extraction. The next step the various extracts of the plant were tried to phytochemical screening. The phytochemical screening shows the presence of flavonoids glycosides carbohydrates and protein. the chloroform and methanolic extracts were subjected to phytochemical screening. The chloroform extract shown the activity against gram positive organism. The phytoconstituents like flavonoids, glycosides are responsible for this activity. The phytochemical studies gave confirmation of the above said result.