The impact of crude oil mixed meal on cellular status and oxidative stress markers in rat’s heart homogenates was studied. 35 Wistar rats of similar weight were randomly divided into 7 groups as follows; Group 1 control (normal chow), Group 2 (Treated with 3.88g/kg crude oil mixed meal), Group 3 (Treated with 7.75g/kg crude oil mixed meal), Group 4 (Treated with 15.51g/kg crude oil mixed meal), Group 5 (Treated with 32.01g/kg crude oil mixed meal), Group 6 (Treated with 62.02g/kg crude oil mixed meal), and Group 7 (myocardial infarct-induced group). Treatments in various groups were administered for 8 weeks (exposure period) and were later withdrawn for 2 weeks (withdrawal period). 5 ml of blood was taken from all groups via cardiac puncture in both phases for analysis for electrolytes estimations, haematological parameters, lipid profiles, and liver enzyme assay. Heart tissues were taken and homogenized and prepared for cardiac oxidative stress markers analysis, were extrapolated and calculated. Results from various laboratory analyses were statistically analysed using ANOVA (SPSS) and presented in tables and charts with level of significance at P ≤0.05. Haematological indices, electrolytes liver enzymes profile, lipid parameters and oxidative stress markers all presented marked increase during the exposure phase of six weeks. In the withdrawal phase, virtually all the above measured parameters were reversed and the corresponding biological effects ameliorated. The implications of the above extrapolates in both phases indicated that crude oil exposure could trigger, electrolyte imbalance, cellular disruptions, liver assault, and can be highly detrimental and delirious to cells while withdrawal from the contaminated meal was observed to reversed the entire scenarios. In conclusion, crude oil contaminated feed on cardiovascular integrity and risk factors could be a huge challenge and a potent pre-disposing scenario to various debilitating diseases of the heart on prolonged exposure.