The present work deals with the use of folklore medicine by tribal and non-tribal communities of Nalgonda district, Telangana state, India for controlling diabetes, a chronic disease. Here it is focused on the use of plant species as folklore medicine to cure diabetes by the ethnic groups. Preliminary phytochemical analysis was carried out with different extracts like distill water, petroleum ether, chloroform and methanol of folk medicine samples and their constituent plant parts from Nalgonda district. The folk medicine and the individual plant parts present in the sample showed the presence of similar kind of phytochemicals with various screening tests for the control of diabetes.