In every field of life, nanotechnology has an impact. Researchers expend their interests on gold nanoparticles synthesis as they provide superior properties for various types of applications. Different physical and chemical methods have synthesized conventionally nanoparticles that have a negative impact on the environment. Due to their unique properties, small size and high area-to-volume ratio, gold nanoparticles show special advantages in this field among nanoparticles. Because of their inert nature, stability, high dispersity, non-cytotoxicity and biocompatibility, these particles have been widely used in various biomedical applications and drug delivery systems.This paper shows the comparison and survey of all the methods.