GM derived seed is one type of powered test item. It is used in 90 day repeat oral toxicity  studies. Powered is administered orally to wistar rats for a period of 90 days. This study also compared the profile of the GM derived cotton seed with the non GM derived cotton seed at the highest does tested. The study was performed to generate information on major systemic toxic effects (if any), target organs and an estimate of the No Observed Effect Level (NOEL) / No Observed Adverse Effect Level (NOAEL) and also reversibility of observed changes, if any, after discontinuation of treatment with the Test Items.