Our aim in the present study was to evaluate the anti-obesity activity of Centella asiatica in high fat diet (HFD), Triton-X and Progesterone induced obese rats and mice. Ethanolic extract od centella asiativa was prepared And the extract is tested with different doses(100mg/kg, 200mg/kg, 400mg/kg) and the efficiency of EECA is comparable to that of orlistat (20mg/kg b.wt), a standard anti-obesity drug. Although food consumption was moderately increased in HFD-fed rats, EECA administration significantly reduced weight gain in them. Serum total cholesterol (TC), triglycerides (TG), low density lipoproteins (LDL) and very low density lipoproteins (VLDL) levels were significantly (P< 0.05) lowered, while high density lipoproteins (HDL) increased in EECA administered with different (HFD, Triton-X, Progesterone) Based on our results we demonstrate that EECA has potential anti-obesity activity. Keywords: Centella asiatica, HFD(high fat diet), progesterone, lipid levels.