Oral analgesics are commonly prescribed  for the treatment of acute and chronic pain, but these  agents often produce adverse systemic effects, which some times are severe ,so topical administration of analgesics is an alternative method. The  aim of  present work is to develop semi solid preparations of natural analgesics like camphor. Three different strengths were prepared which are 25mg,50mg,100mg in two different bases that are hydrophilic and hydrophobic. All the prepared  formulations  were evaluated  for PH, spreadability, diffusion studies. The selected formulations were evaluated for in-vivo studies in comparison with marketed preparations .The  finalized preparation was kept for stability studies according to ICH guidelines. Keywords: Pain, Camphor, Ointment.