Synthesis, characterization and antimicrobial activity of some novel 3-(2-bromoacetyl)phenyl benzoate dithiocarbamate derivatives

3-(2-bromacetyl) phenyl benzoate is key starting material used in synthesis of phenylephrine, (R)-3-[-1-hydroxy-2-(methylamino)ethyl]phenol which is selective α1-adrenergic receptor agonist used primarily as decongestant, as an agent to dilate the pupil, and to increase blood pressure. Hence the current research work was aim to synthesize a series of 3-(2-bromacetyl) phenyl benzoate  derivatives by treatment of secondary amines with carbon disulphide and 3-(2-bromacetyl) phenyl benzoate  in presence of strong base in ethanol afforded the corresponding Dithiocarbamates. Their chemical structures are characterized by 1H &13C NMR, MS, Elemental analysis, and chromatography methods (TLC). The antimicrobial activity was evaluated by their MIC and zone of inhibition by taking Penicillin, Streptomycin and Amphotericin as standard reference drugs. The microbial assay revealed that compounds D4 and D5 showed the most potent antimicrobial activity against variety of bacteria as well as fungal isolates, which may be a promising antimicrobial leading compound for the further research.