American Journal of PharmTech Research

The main objective of present research work was to design, development and characterization of glutathione lyophilized injection. Component excipients were selected based on the preliminary studies. Solubility trials were done to determine the solubility of Glutathione in water with different concentration of sodium bicarbonate. Then glutathione injection was formulated and lyophilized by setting the lyophilization cycle parameters. But, when glutathione was lyophilized alone the cake collapse was observed. So, in order to overcome this problem lyoprotectants (mannitol, lactose, trehalose and sucrose) were added in different concentration i.e. 5% and 10%. The lyophilization cycle was developed for these formulations by changing the process parameter. After formulation development, lyophilization cycle was optimized by reducing the total cycle time. Cycle time reduced at the initial stage of primary drying till the formulation remained stable. First stage of primary drying was reduced to 2520 minutes where the cake remains elegant. The batch L1 developed by FD cycle 11 with 5% trehalose having total lyophilization cycle time 59.75 hours was considered as optimized formulation because it exhibited a good cake formation and pH, moisture content, reconstitution time and assay was found within the range of desired product profile. Short term stability studies were conducted for the optimized formulation as per ICH guidelines for a period of 30 days which revealed that the formulation is stable. It was conclude that the lyophilization technique proves to be an advantage for development of stable injectable dosage form of Glutathione. Keywords: Glutathione, Lyophilized Injection, Injectable Dosage Form.

The solubility and bioavailability of a drug is very important while preparing a formulation. BCS class-II drugs like clopidogrel have the problem of poor bioavailability because of less solubility.so many novel techniques were available to improve the solubility aspects of drug among which solid lipid nanoparticles is a promising approach.in the current study attempts were made to formulate and evaluate clopidogrel loaded solid lipid nanoparticles by employing cutina as lipid and lecithin soya and PEG-400 and TWEEN-80 were used as surfactant systems. Different formulations were prepared and analyzed for drug content, entrapment efficiency, drug release studies. The selected formulations were analyzed with stability studies at two different conditions which is, room temperature and refrigerated conditions.

Improvement of patient’s compliance has always a challenge towards the development of oral drug delivery system. Different dosage forms are available in the market among all oral dosage form is preferred one. However, the incompliance of pediatric & geriatric patients the scientists worked towards fast dissolving solid dosage form to encounter existing drawbacks with unique palatability and rapid disintegration. The concept of fast dissolving tablet came into existence in late 1970s. Recently, fast dissolving drug delivery systems have started gaining popularity and acceptance as new drug delivery system, because they are easy to administer and lead to better patient compliance. For further improvement in existing technologies and newer technologies has been succeeded and still research is going on in improvement with its preparation methodologies all over the globe. Fast dissolution tablets have faster disintegration and dissolution rate and release within 30 seconds as they come in contact with saliva. These systems also obviate the requirement of carry water during drug administration. As fast dissolving tablets falls under desired expectation of safer, convenient and economical solid dosage forms, several techniques have been developed to improve disintegration quality in the recent past years. This article mainly focuses on patented technologies with recent advancement made so far in the field of the fast dissolving tablets.