American Journal of PharmTech Research

Herbal antacid chewing gum is becoming popular as one of the simplest and most patient-compliant ways to treat acidity and related stomach issues. Safe and convenient therapy appears to be in demand given the prevalence of illnesses like GERD (gastroesophageal reflux disease), etc. The advantages of using natural herbal remedies in conjunction with chewing gum therapy seem to be a practical approach. Saliva secretion increases the gastric acid's buffering effect during chewing, ensuring a gradual release of the active substances. This review highlights few of the popular used herbal agent used as antacid and gastroprotective and explains the role of herbs in managing acidity. Different strategies for formulating are discussed along with significant materials and preparation techniques. Few significant parameters to be measured are discussed like acid neutralizing capacity, drug release, texture, stability. Available patents, future prospects are briefly discussed. In conclusion, it can be stated that chewing gums for antacids using herbal agents offer a good substitute. KEY WORDS: Herbal antacid chewing gum, gastroprotective activity, acid neutralization, herbal formulations, chewable dosage form.

Apremilast, an oral phosphodiesterase-4 (PDE-4) inhibitor, is widely used in the treatment of inflammatory diseases such as psoriasis and psoriasis arthritis. However, its poor water solubility to formulate and evaluate a Nanoemulsion (NE) system for Apremilast to enhance its solubility, stability, and bioavailability. A Nanoemulsion was developed using a high energy emulsification method, with a combination of oil, surfactant, and co-surfactant carefully selected based on solubility studies and construction of pseudo-ternary phase diagrams. Various formulations were prepared and evaluated for droplet size, polydispersity index (PDI), zeta potential, and drug encapsulation efficiency. The optimized formulation exhibited a droplet size of below 600 nm, a low PDI, and a stable zeta potential, confirming its stability. According to this report, the Nanoemulsion based delivery system for Apremilast drug could offer significant clinical advantages, particularly in terms of improved pharmacokinetics and enhanced therapeutics outcomes, paving the way for more effective treatment of inflammatory diseases such as psoriasis and psoriatic arthritis. Further in vivo studies are recommended to confirm the observed benefits and to evaluate long term safety and efficacy.

Peptic ulcer is a common gastrointestinal disorder characterized by mucosal damage in the stomach or duodenum due to an imbalance between aggressive factors such as gastric acid and protective mucosal defense. Conventional anti-ulcer drugs, although effective, are often associated with high cost and adverse effects. Therefore, the present study aimed to develop and evaluate polyherbal floating tablets as a safer and more effective alternative for gastric ulcer management. The formulation incorporated extracts of Annona squamosa with sodium bicarbonate as a gas-generating agent to enhance buoyancy and prolong gastric retention. Tablets were prepared using the direct compression method by blending plant extracts with suitable polymers and excipients. The prepared formulations were evaluated for physicochemical properties and showed satisfactory results. The floating drug delivery system demonstrated potential for prolonged gastric residence time, which may improve therapeutic efficacy and patient compliance.