Current Issue
Volume 16, Issue 4 - 2026 (August 2026 Issue 4 )
Issue Details:
Volume 16 Issue 4 (August 2026 Issue 4)Issue Description:
Welcome to the 2026 issue of American Journal of PharmTech Research. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.
We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.
As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.
Dr H J Patel
Editor-in-Chief
American Journal of PharmTech Research
Articles in This Issue
THE ROLE OF NANOPARTICLES AS A CARDIOPROTECTIVE STRATEGY AGAINST DOXORUBICIN INDUCED CARDIOTOXICITY
Doxorubicin is a potent chemotherapeutic agent, but its clinical use is limited by dose-dependent cardiotoxicity, which can lead to cardiomyopathy and heart failure. This review discusses the potential of phyto constituent-based nanoformulations as cardioprotective adjuvants against doxorubicin. Encapsulating cardioprotective agents like herbal extracts, antioxidants, and anti-inflammatory co0mpounds encompassing nanoparticles enhances their bioavailability and targeted delivery to cardiomyocytes. Various nanoparticle systems including polymeric (solid lipid), inorganic (mesoporous silica, gold), and nanocomposites have shown promise in mitigating doxorubicin-induced oxidative stress, apoptosis, and cardiac injury in preclinical studies. The therapeutic effects of curcumin, resveratrol, thymoquinone, L-carnitine, and other agents were improved when delivered via nanoparticle. However, optimization of nanoparticle properties, targeted delivery strategies, long-term safety assessments, and clinical translation remain to be addressed. Nonetheless, nanoparticle-mediated delivery of cardioprotective agents holds great potential for reducing doxorubicin-associated cardiotoxicity and improving chemotherapeutic outcomes for cancer patients.
Contributors:
Nanotechnology-Based Bilayer Tablet Approaches for Antidepressant Drug Delivery in Depression Management
Depression is a chronic neuropsychiatric disorder characterized by emotional instability, sadness, sleep disturbances, cognitive impairment, and loss of interest in daily activities. Conventional antidepressant therapies are associated with delayed onset of action, systemic adverse effects, poor patient compliance, low bioavailability, and inadequate blood–brain barrier penetration. Advanced pharmaceutical technologies including bilayer tablet systems and nanotechnology-based drug delivery approaches have emerged as promising strategies for improving antidepressant therapy. Bilayer tablets provide immediate and sustained drug release profiles within a single dosage form, thereby improving therapeutic efficacy and patient adherence. Nanotechnology-based systems including nanoparticles, nanoemulsions, lipid carriers, and intranasal formulations improve targeted brain delivery and reduce systemic toxicity. The present review discusses depression pathophysiology, antidepressant mechanisms, bilayer tablet technologies, tablet preparation methods, evaluation parameters, marketed antidepressant formulations, and recent advancements in nano-based antidepressant delivery systems. The review further highlights the future potential of advanced pharmaceutical approaches in depression management.
Contributors:
Polyherbal Antibacterial Lipsticks as Next-Generation Multifunctional Cosmeceuticals: Formulation Strategies, Antimicrobial Mechanisms, Evaluation, Lip Protection, and Sustainable Commercial Prospects
The growing demand for safe, multifunctional, and sustainable cosmetic products has accelerated the development of polyherbal antibacterial lipsticks as next-generation cosmeceuticals. Unlike conventional lipsticks, which may contain synthetic pigments, preservatives, and heavy metals associated with irritation, allergic reactions, and safety concerns, polyherbal formulations utilize bioactive plant-derived ingredients rich in flavonoids, phenolics, tannins, terpenoids, and essential oils. These phytoconstituents provide antimicrobial, antioxidant, anti-inflammatory, moisturizing, and wound-healing properties while enhancing lip aesthetics. This review highlights recent advances in the formulation of polyherbal antibacterial lipsticks, including the selection of natural colorants, waxes, oils, herbal extracts, and functional phytochemicals. Particular emphasis is placed on antimicrobial mechanisms such as cell membrane disruption, inhibition of microbial growth, suppression of biofilm formation, and modulation of inflammatory pathways. Physicochemical, microbiological, and stability evaluation parameters essential for product quality and standardization are also discussed. Furthermore, emerging technologies including nanoherbal delivery systems, liposomes, phytosomes, and sustainable packaging strategies are explored for improving product performance and consumer acceptance. The review also addresses challenges related to pigment stability, quality control, regulatory compliance, and commercialization. Overall, polyherbal antibacterial lipsticks represent a promising convergence of traditional herbal knowledge and modern cosmetic science, offering safe, effective, multifunctional, and environmentally sustainable alternatives for advanced lip care and protection.
Contributors:
Design and Analysis of Antidiabetic Chocolate Containing Mangifera indica Extract
Chocolate is a widely enjoyed commodity across all age groups however doctors often advise against its consumption for individuals with conditions such as diabetes, high blood pressure, obesity, and coronary artery disease. This study aimed to develop a medicated chocolate that not only allows patients to enjoy chocolate but also helps prevent diabetes. Mangifera indica (mango leaves) is known for its antidiabetic properties due to its high concentration of antioxidants, vitamins, polyphenols, and flavonoids, which aid in lowering blood sugar levels. The formulation of antidiabetic chocolate was achieved using an hydroalcoholic extract of Mangifera indica, Cocoa powder, Cocoa butter, Monk fruit, and Erythritol in optimized proportions. The chocolate was then evaluated based on physical parameters such as appearance, taste, odour, consistency, blooming test, physical stability, and drug content determination using UV spectroscopy. Additionally, an MTT assay was conducted against INS-1 832/3 cell lines, with Metformin as the standard, to assess cell proliferation and cytotoxicity. The study successfully incorporated mango leaf powder into chocolate, masking the unpleasant taste of the medicinal components while maintaining a smooth, silky texture. The results indicated that the formulated chocolate was safe for consumption without posing any risk of adverse effects.
Contributors:
Synthesis, characterization and biological evaluation of isatin based Schiff base derivatives and Thiazolidine -4-one derivatives
Isatin (1H-indole-2,3-dione) and its derivatives belong to an important class of indole-fused heterocyclic compounds. Isatin serves as a versatile intermediate for the synthesis of a wide range of biologically active heterocycles. The present work provides a detailed account of the synthesis of isatin-based Schiff bases and their corresponding thiazolidine-4-one derivatives, which can be further utilized for the development of novel heterocyclic molecules.The isatin moiety exhibits a broad spectrum of biological and pharmacological activities, including antihypertensive, analgesic, anthelmintic, antitumor, antiviral, antifungal, anticonvulsant, anti-Parkinson, anti-HIV, anti tubercular, and antioxidant activities.In the present study, a series of isatin and Schiff base derivatives were synthesized. Initially, isatin was reacted with acetaldehyde in the presence of sodium hydroxide and ethanol to yield an aldol-condensed product at the C-2 position. This intermediate was further reacted with nitro-substituted benzene diamines in ethanol under basic conditions to form Schiff base derivatives. The synthesized Schiff bases were subsequently cyclized with thioglycolic acid to obtain thiazolidine-4-one derivatives.The progress and completion of the reactions were monitored by thin-layer chromatography (TLC). The synthesized compounds were evaluated for anthelmintic activity using earthworms as the experimental model. Structural characterization of the compounds was carried out using ¹H-NMR spectroscopy and mass spectrometry, which confirmed the proposed structures.