Formulation and Evaluation of pH Dependent Zolmitriptan in-Situ Nasal Gel

Development of pH sensitive zolmitriptanin-situnasal gel was aimed to improve absorption and patient compliance. In the present research work, mixture of Carbopol 940 and Hydroxypropylmethylcellulose K100 were used to confer pH sensitive gelation property. Different formulation was prepared by varying the concentrations of Carbopol 940 and HPMC K100.These formulations were evaluated for parameters like pH, drug content, viscosity, mucoadhesive strength, gel strength, in-vitro drug release, in-vitro permeation and drug excipients compatibility. In this formulation the release profile depend on the concentration of Carbopol 940 and HPMC K100. A 32 factorial design was applied to see the effect of variables Carbopol 940 (X1) and HPMC K100 (X2) on the various models to ascertain kinetic of drug release. Regression analysis and analysis of variance were performed for dependent variables. The results of the F-statistics were used to select the most appropriate model. Formulation containing Carbopol 940 (0.1%) and HPMC K100 (0.2%) was found to be optimum. The study indicate that the formulation was effective in providing in-vitro release of drug and the mucoadhesive formulation.