An Efficient Synthesis of Disubstituted Pyrazoles From 2-Propyn-1-ol Through Propargyl Hydrazides

An efficient synthesis process access to disubstituted pyrazoles have been demonstrated from 2-propyn-1-alcohols using an effective catalyst Polymer bound pTSA. This conversion proceeds via an acid catalyzed propargylation of N,N-diprotected hydrazines followed by base-mediated cyclization to furnish 3,5-Disubstituted-1H-pyrazoles in optimum yields.