Formulation and Evaluation of Fast Dissolving Tablets of An Anti Ulcer Drug by Sublimation Method

The purpose of present research was to formulate and develop the patient friendly pantoprazole sodium fast dissolving tablets using sublimation method to achieve rapid dissolution. In this study, an attempt was made to fasten the drug release from the oral tablets by incorporating the superdisintegrants and camphor/ammonium bicarbonate as subliming agents. The prepared fast dissolving tablets were subjected to pre-compression analysis and evaluated for hardness, weight variation, friability, wetting time, water absorption ratio and disintegration time. From the results of in vitro drug release studies, the formulation F9 exhibited fast release profile of about 95.21% in 14 min and disintegration time 90 sec when compared with other formulations. For the optimized formulation F9, the initial dissolution rate was 38.82% / 2 min. Fourier transform infrared spectroscopy studies revealed that there was no possibility of interactions between drug and excipients. The present study demonstrated potential for rapid absorption, improved bioavailability, effective therapy and patient compliance.