RP-HPLC Technique for the Assurance of Mebendazole In Unadulterated and In Tablet Measurements

Q: Who are the authors of this article and where was it published?

M.Gopala Krishna, M.Subba Rao. Published in American Journal of PharmTech Research, Vol. 10, No. 1, (2020).

Q: Is the full text of this article freely available?

Yes. This article is published open access under CC BY 4.0. The full text and PDF can be downloaded free of charge via https://doi.org/10.46624/ajptr.2020.v10.i1.017.

Q: What are the key topics covered in this article?

Mebendazole, tablet measurements and ICH Guidelines..

M.Gopala Krishna; M.Subba Rao

doi:10.46624/ajptr.2020.v10.i1.017

Published

RP-HPLC Technique for the Assurance of Mebendazole In Unadulterated and In Tablet Measurements

M.Gopala Krishna

,

M.Subba Rao

DOI: 10.46624/ajptr.2020.v10.i1.017

Published in February 2020 Issue 1 (Vol. 10, Issue 1, 2020)

RP-HPLC Technique for the Assurance of Mebendazole In Unadulterated and In Tablet Measurements - Issue cover

Keywords

Mebendazole tablet measurements and ICH Guidelines.

Abstract

A new RP-HPLC method for the assay of mebendazole in in unadulterated and in tablet measurements has been developed and validated. The present chromatographic study was carried on μ Bondapak® C18 (250X4.6 mm), 5μm with a flow rate of 1.0mL/min of mobile phase and UV detection at of 218nm and ambient column temperature with mobile phase of NaH2PO4 buffer(pH-5.0) and acetonitrile in the ratio of 65:35%v/v as the mobile phase. The retention time for mebendazole were found to be 2.60mins respectively. The developed RP-HPLC method was validated as per ICH guidelines and was found to be suitable for pharmacokinetic studies.

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Authors (2)

M.Gopala Krishna

Acharya Nagarjuna University, ...Acharya Nagarjuna University, Guntur, A.P, IndiaAcharya Nagarjuna University, Guntur, A.P, IndiaAcharya Nagarjuna University, Guntur, A.P, India

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M.Subba Rao

Acharya Nagarjuna University, ...Acharya Nagarjuna University, Guntur, A.P, IndiaAcharya Nagarjuna University, Guntur, A.P, IndiaAcharya Nagarjuna University, Guntur, A.P, India

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Article Information

Published in:

February 2020 Issue 1 (Vol. 10, Issue 1, 2020)

Article ID:

AJPTR101017

Paper ID:

AJPTR-01-002347

Pages:

1-10

Published Date:

2020-02-01

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Krishna, M., & Rao, M. (2020). RP-HPLC Technique for the Assurance of Mebendazole In Unadulterated and In Tablet Measurements. American Journal of PharmTech Research, 10(1), 1-10. https://doi.org/10.46624/ajptr.2020.v10.i1.017