Synthesis and Antimicrobial Studies of Some New Perbenzoylated N-Glucosyl Benzothiazolyl Carbamides and Carbamates

  As part of ongoing studies in developing new antimicrobials, a class of structurally novel perbenzolylated glucosyl benzothiazolyl carbamides and carbamates were synthesized by the interaction of tetra-O-benzoyl-β-D-glucosyl isocyanate with substituted benzothiazoles and various alcohols. The identities of these newly synthesized compounds were established on the basis of usual chemical transformations and IR, 1H NMR, and Mass spectral studies and evaluated for their in vitro antimicrobial activities using standard cup plate method against bacteria E. coli, P. aeruginosa, P. vulgaris, B. cereus, S. aureus and fungi A. niger, C. albicans.