In Vivo Evaluation of Piroxicam Release In Cellulose Acetate Phthalate Films In and Organogels In Rats

Three groups of rats each consists of five rats were used for this study. Edema was induced by injecting a solution of carrageenan in saline intradermally. Transdermal cellulose acetate phthalate film (with IPM as penetration enhancer) with highest drug release and organogels formulation (Fl: Span 60: 17; Tween 20: 3; Soya bean oil: 40; Drug: 2 and Water: 40) with the highest spreadability, the lowest viscosity and the optimized drug release over 8 h was applied. Results from the in vivo pharmacological study revealed that gel preparation was superior to the patch in reducing the edematous swelling in the rats feet pad over the 1 day of application.