A Detailed Review on Novel Solubility Enhancement Techniques

Approximately 40% of the marketed drugs and 70 to 90% of the drugs in development are poorly water soluble. Solubility plays a crucial role in the absorption of the drugs ingested orally. As most of the drugs are poorly soluble the solubility enhancement is the prime requisite to enhance dissolution, bioavailability and therapeutic efficacy. Several approaches as physical modification, pH adjustment, Super critical fluid technology, liquisolid techniques and chemical modifications are to enhance the solubility. Physical methods include particle size reduction, solubility enhancement by carriers, by surfactants, by complexation chemical modifications include Hydrotrophy, co-solvency, nano technology, salt formation and co-crystallization. This review mainly focuses on novel techniques to enhance solubility includes liquisolid system, Spherical agglomeration, melt sonocrystallization, Hydrotrophy, Natural deep eutectic solvents nano technology-based methods, solid state engineering, advanced formulation strategies include self-emulsifying drug delivery systems, and supercritical fluid technology and other innovative techniques like and micro wave assisted techniques.