Synthesis of 4-(2’-Alkyl/Aryl Benzimidazolo N-1-Yl-Methyl) – 7-Hydroxy Coumarins

The synthesis of a number of 4-(2’-alkyl/aryl benzimidazolo N-1-yl-methyl) -7 hydroxycoumarins containing pharmacophores of the coumarin and benzimidazole in a single molecule has been achieved.  4-Chloromethyl coumarins is used as N-alkylating (N-alkylation of benzimidazole) agent which is prepared by Pechmann condensation. 2-Substituted benzimidazoles were prepared by interaction of carboxylic acids and o-phenylenediamine. The structures of synthesized compounds have been assigned on the basis of chemical tests, IR, 1H NMR, and Mass spectral data.