Preformulation Studies of Drugs and Excipients for the Formulation of Salmon Fish oil Nanoemulsion Gel for the Treatment of Psoriasis

Psoriasis is a prolonged, immune-mediated inflammatory skin disease. It is characterized by sharply demarcated, red, scaly, coin-sized skin lesions most often on the elbows, hands, knees, scalp and feet. Around 10% of individuals with psoriasis develop arthritis, which may affect the hands, feet, wrists, ankles, neck and lower back. In some cases joints become deformed, causing significant disability. The worldwide prevalence of psoriasis is around 2%, but studies in developed countries have reported higher incidence rates of on average about 4.6%.  In India the prevalence of psoriasis fluctuates from 0.44 to 2.8%, it is two times more common in males compared to females, and most of the patients are in their third or fourth decade at the time of presentation. Nearly two thirds of people with psoriasis have a mild form of the disease, Therefore in most of the cases first line treatment approach is topical. Betamethsone dipropionate (BD) loaded in omega-3- fatty acid fish oil nanoemulsion for the healthier absorption of BD in deeper layer of the skin to stop further progression of inflammatory cycle. For the preparation of nanoemulsion different types of preformulation studies require to perform because every drug has its specific intrinsic chemical and physical property which has been consider before development of pharmaceutical formulation. This property provides the framework for drug's combination with pharmaceutical ingredients in the fabrication of dosage form.