Lavanya B

Oral medicated jellies are a promising alternative dosage forms for patients who experience difficulty in swallowing the conventional dosage forms like tablets and capsules. The present study aimed to formulate and evaluate oral medicated jellies containing Diclofenac sodium, a non-steroidal anti-inflammatory drug, and Dicyclomine HCl, an antispasmodic agent, using different concentrations and combinations of gelatin and xanthan gum. Solid dispersion of with beta- cyclodextrin was prepared by the kneading method. Nine formulations of oral jellies (F1–F9) were prepared by the heating and congealing method using gelatin, xanthan gum, and their combinations. The formulations were evaluated for physical appearance, compatibility using FTIR, weight variation, pH, syneresis, drug content, and in-vitro drug release. The dissolution studies were performed using USP apparatus II in phosphate buffer pH 6.8 for 120 min. Dissolution efficiency (%) and mean dissolution time (MDT) were determined. The results of FTIR studies indicated compatibility between the drugs and excipients. The formulations exhibited acceptable physicochemical properties. Formulation F4 showed the highest drug release of 91.11 ± 0.22% and 94.81 ± 0.21% at 30 min for Diclofenac sodium and Dicyclomine HCl, respectively. The Dissolution efficiency of formulation F4 was 57.31% and 68.75% at 30 min, while the mean dissolution time was 16.56 min and 15.08 min, respectively. Formulation F4 was selected as the best formulation due to high dissolution efficiency and rapid drug release, demonstrating the potential of oral medicated jelly as a patient-friendly dosage form.

The present study aims to investigate the phytochemical screening, antioxidant and anti-diabetic activity of commonly used fruits, Musa acuminata Red Dacca (Red Banana), Citrus sinensis (Orange) and Phyllathus emblica (Amla). Edible part of Phyllanthus emblica, Musa acuminata Red Dacca and peel of Citrus sinensis are taken for the study. The phytochemical screening of ethanolic extract of Musa acuminata revealed strong presence of carbohydrates and glycosides and moderate presence of tannins, proteins, flavonoids, steroids and phenols. The ethanolic extract of Citrus sinensis showed abundance of flavonoids and least presence of carbohydrates, proteins and steroids. Strong presence of phenol was shown in Phyllanthus emblica and all the others were present in least amount. The antioxidant activity was determined by ferric reducing power assay (FRP) where Phyllanthus emblica showed maximum activity that was followed by Citrus sinensis peel and then Musa acuminata. α-Amylase inhibitory assay was performed to detect the antidiabetic activity of these fruits by comparing with  commercially available drug Okamet. It was Phyllanthus emblica that used lowest concentration to inhibit the enzyme which was found similar to positive commercial standard Okamet that is used for reducing blood sugar level. Hence it can be concluded that Phyllanthus emblica has good antioxidant and antidiabetic property than Musa acuminata and Citrus sinensis.