Membrane stabilizing activity – a possible Mechanism of action for the anti-inflammatory Activity of Psidium Guajava in rats

In an effort to scientifically appraise the mechanism of action of Psdium guajava stem bark and leaves, the present study was carried out to investigate the cell membrane stabilizing anti-inflammatory activities of methanol extracts of psidum guajava on experimental animal model at three different dose levels – 5mg/kg, 10mg/kg and 15mg/kg. Aspirin (10mg/kg) was used as standard reference cell membrane stabilizing agent for comparison. This research work was carried out using Wistar strain albino rats weighing 150g-175g. The extractive inhibited heat- induced haemolysis of erythrocytes in vitro. The methanol extract of Psidum guajava stem- bark demonstrated 89.23%, 93.94% and 103.66% inhibition while the leave extract demonstrated 51.40%, 51.43%, 61.40% and 44.29% of hemolysis of RBC caused by heat, in a dose- dependent manner – 5mg/kg, 10mg/kg and 15mg/kg respectively. Results were considered significant at p ≤0.05.