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American Journal of PharmTech Research

American Journal of PharmTech Research

Published

A NOVEL NANOEMULSION FORMULATION OF APREMILAST FOR PSORIASIS

Published in August 2026 Issue 4 (Vol. 16, Issue 4, 2026)

A NOVEL NANOEMULSION FORMULATION OF APREMILAST FOR PSORIASIS - Issue cover

Abstract

Apremilast, an oral phosphodiesterase-4 (PDE-4) inhibitor, is widely used in the treatment of inflammatory diseases such as psoriasis and psoriasis arthritis. However, its poor water solubility to formulate and evaluate a Nanoemulsion (NE) system for Apremilast to enhance its solubility, stability, and bioavailability. A Nanoemulsion was developed using a high energy emulsification method, with a combination of oil, surfactant, and co-surfactant carefully selected based on solubility studies and construction of pseudo-ternary phase diagrams. Various formulations were prepared and evaluated for droplet size, polydispersity index (PDI), zeta potential, and drug encapsulation efficiency. The optimized formulation exhibited a droplet size of below 600 nm, a low PDI, and a stable zeta potential, confirming its stability. According to this report, the Nanoemulsion based delivery system for Apremilast drug could offer significant clinical advantages, particularly in terms of improved pharmacokinetics and enhanced therapeutics outcomes, paving the way for more effective treatment of inflammatory diseases such as psoriasis and psoriatic arthritis. Further in vivo studies are recommended to confirm the observed benefits and to evaluate long term safety and efficacy.

References

  1. [1]REFERENCES
  2. [2]1. Metal MI. A systematic review of worldwide epidemiology of psoriasis. Journal of the European Academy of Dermatology and Venereology. 2017; 31(2): 205-212. doi:10.1111/jdv.13854.
  3. [3]2. Sheikh SN et al. Formulation development and optimization using Nanoemulsion technique: a technical note. AAPS PharmSciTech. 2007; 8(2): 28. doi:10.1208/pt0802028.
  4. [4]3. Forgiarini AM et al. Formulation of Nano emulsions by Low energy emulsification methods at Constant temperature. Langmuir. 2001; 17: 2076-2083.
  5. [5]4. Shah PK et al. Nanoemulsion: A Pharmaceutical review. Systematic Reviews in Pharmacy. 2010; 1: 24-32.
  6. [6]5. Zhang LW et al. Oil components modulate the skin delivery of 5-aminolevulinic acid and its ester prodrug from oil in water and water in oil Nanoemulsions. International Journal of Nanomedicine. 2011; 6: 693-704. doi:10.2147/IJN.S17524.
  7. [7]6. Rai VK et al. Nanoemulsion as Pharmaceutical carrier for dermal and transdermal drug delivery: Formulation development, stability issues, basic considerations and applications. Journal of controlled release. 2018; 270: 203-225. doi:10.1016/j.jconrel.2017.11.049.
  8. [8]7. Innocente N et al. Effect of high pressure homogenizationon droplet size distribution and rheological properties of ice cream mixes. Journal of dairy science. 2009; 92(5): 1864-1875. doi:10.3168/jds.2008-1797.
  9. [9]8. Schultz S et al. High Pressure homogenization as a process for Emulsion Formation. Chemical Engineering & Technology. 2004; 27: 361-368.
  10. [10]9. Rizwan AA, M Ahmad FJ. et al. Nanoemulsion components screening and selection: a technical note. AAPS PharmSciTech. 2009; 10(1): 69-76.
  11. [11]10. Jafari SM et al. Production of sub micro emulsions by ultrasound and microfluidization techniques. Journal of Food Engineering. 2007; 82: 478-488.
  12. [12]11. Hsieh CW et al. Preparing glabridin-in-water Nanoemulsion by high pressure homogenization with response surface methodology. Journal of Oleo Science. 2012; 61(9): 483-9. doi:10.5650/jos.61.483.
  13. [13]12. Lovelyn C and Anthony AA. Current State of Nanoemulsions in Drug Delivery. Journal of Biomaterials and Nanobiotechnology. 2011; 2: 626-639.
  14. [14]13. Maa YF, Hsu CC. Performance of sonication and microfluidization for liquid liquid emulsification. Pharma Dev Technol. 1999; 4(2): 233-240.
  15. [15]14. Villalobos-Castillejos F et al. Fabrication of Nanoemulsions by Microfluidization. Nanoemulsions: Formulation, Applications and Charecterizations. 2018; 207-232. doi:10.1016/B978-0-12-811838-2.00008-4
  16. [16]15. Pinnamaneni S. et al. Comparison of oil in water emulsions manufactured by microfluidization and homogenization. Die Pharmazie. 2003; 58(8): 554-558.
  17. [17]16. Leong T S H. et al. Minimizing oil droplet size using ultrasonic emulsification. Ultrasonics sonochemistry. 2009; 16(6): 721-727. doi:10.1016/j.ultsonch.2009.02.008.
  18. [18]17. Abismail B. et al. Emulsification by ultrasound: drop size distribution and stability. Ultrasonics sonochemistry. 1999; 6(1): 75-83. doi:10.1016/s1350-4177(98)00027-3.
  19. [19]18. Amiji MM. et al. Nanoemulsion Formulations for improved oral delivery of Poorly soluble drugs. NSTI-Nanotech 2006, www.nsti.org, ISBN 0-9767985-6-5 Vol. 1, 2006.
  20. [20]19. Ghosh V et al. Ultrasonic emulsification of food grade Nanoemulsion formulation and evaluation of its bactericidal activity. Ultrasonic sonochemistry. 2013; 20(1): 338-344. doi:10.1016/j.ultsonch.2012.08.010.
  21. [21]20. Salvia-Trujillo L et al. Edible Nanoemulsions as carriers of Active ingredients: A Review. Annual review of food science and technology. 2017; 8: 439-466. doi:10.1146/annurev-food-030216-025908.
  22. [22]21. Solans C and Sole I. Nanoemulsions: Formation by low energy methods. Current opinion in Colloid and interface Science. 2012; 17: 246-254.
  23. [23]22. Sole I et al. Nanoemulsions prepared by the phase inversion composition method: Preparation variables and scale up. Journal of colloid and interface science. 2010; 344(2), 417-423.
  24. [24]23. Armanet L and David H. Phase inversion of Polyacrylamide based inverse emulsions: Influence of inverting surfactant type and concentration. Journal of Applied Polymer Science. 2007; 103: 3567-3584.
  25. [25]24. Lopez M, Juan C et al. Spontaneous Emulsification: Mechanisms, Physicochemical Aspects, Modeling and applications. Journalof Dispersion Science and Technology. 2002; 23: 219-268.
  26. [26]25. Sole I et al. Study of Nanoemulsion formation by dilution of microemulsions. Journal of colloid and interface science. 2012. 376(1): 133-139. doi:10.1016/j.jcis.2012.02.063.
  27. [27]26. Kheawfu K et al. Development and characterization of clove oil nanoemulsions and self microemulsifying drug delivery systems. Journal of Drug Delivery Science and Technology. 2018; 46: 330-338.
  28. [28]27. Jaiswal M et al. Nanoemulsion: An advanced mode of drug delivery system. 3 Biotech. 2015; 5(2): 123-127. doi:10.1007/s13205-014-0214-0.
  29. [29]28. Patel N, Chaudhary S, Chaudhary A. Formulation Development and Evaluation of Apremilast Nanoemulsion. Research Journal of Pharmacy and Technology. 2023; 16(6): 2859-2866. Doi:10.52711/0974-360X.2023.00471.
  30. [30]29. Ahmed M.M., Anwer, M.K., Fatima, F., Alali, A.S., Kalam, M.A., Zafar, A., Alshehri, S., Ghoneim, M.M. Development of Apremilast Nanoemulsion loaded Chitosan Gels: In vitro evaluations and Anti inflammatory and wound healing studies on a rat model. Gels. 2022; 8: 253. doi:10.3390/gels8050253.
  31. [31]30. Ruth HS. et al. Phase studies and particle size analysis of oil-in-water phospholipid microemulsions. International Journal of Pharmaceutics. 1995; 116: 253-261.

Authors (2)

Dr. Ajit Kumar Pandey

Shri Shankaracharya Profession...

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Vandana Bhagat

Shri Shankaracharya Profession...

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AJPTR4160012

AJPTR-02-002492

190-204

2026-08-31

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How to Cite

Dr. Ajit Kumar Pandey & Bhagat (2026). A NOVEL NANOEMULSION FORMULATION OF APREMILAST FOR PSORIASIS. American Journal of PharmTech Research, 16(4), 190-204. https://ajptr.com/articles/AJPTR4160012

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