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American Journal of PharmTech Research

American Journal of PharmTech Research

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📢 Latest Update:  Call for Papers 2026 — AJPTR Now Accepting Manuscripts for July 2026 | Open Access | Fast Review | Deadline: July 15, 2026

📢 Latest Update:  Call for Papers 2026 — AJPTR Now Accepting Manuscripts for July 2026 | Open Access | Fast Review | Deadline: July 15, 2026

Volume 16, Issue 4 - 2026 (August 2026 Issue 4)

Volume 16 Issue 4 Cover

Issue Details:

Volume 16 Issue 4
Published:Aug 1, 2026

Editorial: August 2026 Issue 4

Welcome to the 2026 issue of American Journal of PharmTech Research. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr H J Patel
Editor in Chief
American Journal of PharmTech Research

Articles in This Issue

Showing 9 of 9 articles
Research PaperID: AJPTR4160001Pages 1-19

THE ROLE OF NANOPARTICLES AS A CARDIOPROTECTIVE STRATEGY AGAINST DOXORUBICIN INDUCED CARDIOTOXICITY

GUNA P, GOKULAKANNAN B, TAMIL SELVANAN S, JENIFER C, NAPPINNAI M

Doxorubicin is a potent chemotherapeutic agent, but its clinical use is limited by dose-dependent cardiotoxicity, which can lead to cardiomyopathy and heart failure. This review discusses the potential of phyto constituent-based nanoformulations as cardioprotective adjuvants against doxorubicin. Encapsulating cardioprotective agents like herbal extracts, antioxidants, and anti-inflammatory co0mpounds encompassing nanoparticles enhances their bioavailability and targeted delivery to cardiomyocytes. Various nanoparticle systems including polymeric (solid lipid), inorganic (mesoporous silica, gold), and nanocomposites have shown promise in mitigating doxorubicin-induced oxidative stress, apoptosis, and cardiac injury in preclinical studies. The therapeutic effects of curcumin, resveratrol, thymoquinone, L-carnitine, and other agents were improved when delivered via nanoparticle. However, optimization of nanoparticle properties, targeted delivery strategies, long-term safety assessments, and clinical translation remain to be addressed. Nonetheless, nanoparticle-mediated delivery of cardioprotective agents holds great potential for reducing doxorubicin-associated cardiotoxicity and improving chemotherapeutic outcomes for cancer patients.

DoxorubicincardiotoxicityNanoparticlesCardioprotective agentsOxidative stressApoptosis.
357,616 views
107,175 downloads

Contributors:

 GUNA P
,
 GOKULAKANNAN B
,
 TAMIL SELVANAN S
,
 JENIFER C
,
 NAPPINNAI M
Research PaperID: AJPTR4160003Pages 35-70

Polyherbal Antibacterial Lipsticks as Next-Generation Multifunctional Cosmeceuticals: Formulation Strategies, Antimicrobial Mechanisms, Evaluation, Lip Protection, and Sustainable Commercial Prospects

Samyuktha Metta, Arunabha Mallik, Gollapally Sri Vaishnavi, Burra Madhuri, Kola Vijayalaxmi, Komma Srilatha

The growing demand for safe, multifunctional, and sustainable cosmetic products has accelerated the development of polyherbal antibacterial lipsticks as next-generation cosmeceuticals. Unlike conventional lipsticks, which may contain synthetic pigments, preservatives, and heavy metals associated with irritation, allergic reactions, and safety concerns, polyherbal formulations utilize bioactive plant-derived ingredients rich in flavonoids, phenolics, tannins, terpenoids, and essential oils. These phytoconstituents provide antimicrobial, antioxidant, anti-inflammatory, moisturizing, and wound-healing properties while enhancing lip aesthetics. This review highlights recent advances in the formulation of polyherbal antibacterial lipsticks, including the selection of natural colorants, waxes, oils, herbal extracts, and functional phytochemicals. Particular emphasis is placed on antimicrobial mechanisms such as cell membrane disruption, inhibition of microbial growth, suppression of biofilm formation, and modulation of inflammatory pathways. Physicochemical, microbiological, and stability evaluation parameters essential for product quality and standardization are also discussed. Furthermore, emerging technologies including nanoherbal delivery systems, liposomes, phytosomes, and sustainable packaging strategies are explored for improving product performance and consumer acceptance. The review also addresses challenges related to pigment stability, quality control, regulatory compliance, and commercialization. Overall, polyherbal antibacterial lipsticks represent a promising convergence of traditional herbal knowledge and modern cosmetic science, offering safe, effective, multifunctional, and environmentally sustainable alternatives for advanced lip care and protection.

Polyherbal antibacterial lipstickMultifunctional cosmeceuticalsAntimicrobial phytochemicalsLip protectionHerbal cosmeticsLip microbiome+4 more
357,714 views
107,343 downloads

Contributors:

 Samyuktha Metta
,
 Arunabha Mallik
,
 Gollapally Sri Vaishnavi
,
 Burra Madhuri
,
 Kola Vijayalaxmi
,
 Komma Srilatha
Research PaperID: AJPTR4160004Pages 71-83

Design and Analysis of Antidiabetic Chocolate Containing Mangifera indica Extract

Krishna Ochani, Monu Mishra, Dr.Swati Patil

Chocolate is a widely enjoyed commodity across all age groups however doctors often advise against its consumption for individuals with conditions such as diabetes, high blood pressure, obesity, and coronary artery disease. This study aimed to develop a medicated chocolate that not only allows patients to enjoy chocolate but also helps prevent diabetes. Mangifera indica (mango leaves) is known for its antidiabetic properties due to its high concentration of antioxidants, vitamins, polyphenols, and flavonoids, which aid in lowering blood sugar levels. The formulation of antidiabetic chocolate was achieved using an hydroalcoholic extract of Mangifera indica, Cocoa powder, Cocoa butter, Monk fruit, and Erythritol in optimized proportions. The chocolate was then evaluated based on physical parameters such as appearance, taste, odour, consistency, blooming test, physical stability, and drug content determination using UV spectroscopy. Additionally, an MTT assay was conducted against INS-1 832/3 cell lines, with Metformin as the standard, to assess cell proliferation and cytotoxicity. The study successfully incorporated mango leaf powder into chocolate, masking the unpleasant taste of the medicinal components while maintaining a smooth, silky texture. The results indicated that the formulated chocolate was safe for consumption without posing any risk of adverse effects.

Antidiabetic chocolateMangifera indicaMango leaf extractDiabetes mellitusFunctional foodMTT assay+1 more
357,875 views
107,280 downloads

Contributors:

 Krishna Ochani
,
 Monu Mishra
,
 Dr.Swati Patil
Research PaperID: AJPTR4160005Pages 84-97

Synthesis, characterization and biological evaluation of isatin based Schiff base derivatives and Thiazolidine -4-one derivatives

kadapal Gopal, J Savithri,, D. Radha, K. Vijayasantoshalakshmi,, D. Anantha prasad

Isatin (1H-indole-2,3-dione) and its derivatives belong to an important class of indole-fused heterocyclic compounds. Isatin serves as a versatile intermediate for the synthesis of a wide range of biologically active heterocycles. The present work provides a detailed account of the synthesis of isatin-based Schiff bases and their corresponding thiazolidine-4-one derivatives, which can be further utilized for the development of novel heterocyclic molecules.The isatin moiety exhibits a broad spectrum of biological and pharmacological activities, including antihypertensive, analgesic, anthelmintic, antitumor, antiviral, antifungal, anticonvulsant, anti-Parkinson, anti-HIV, anti tubercular, and antioxidant activities.In the present study, a series of isatin and Schiff base derivatives were synthesized. Initially, isatin was reacted with acetaldehyde in the presence of sodium hydroxide and ethanol to yield an aldol-condensed product at the C-2 position. This intermediate was further reacted with nitro-substituted benzene diamines in ethanol under basic conditions to form Schiff base derivatives. The synthesized Schiff bases were subsequently cyclized with thioglycolic acid to obtain thiazolidine-4-one derivatives.The progress and completion of the reactions were monitored by thin-layer chromatography (TLC). The synthesized compounds were evaluated for anthelmintic activity using earthworms as the experimental model. Structural characterization of the compounds was carried out using ¹H-NMR spectroscopy and mass spectrometry, which confirmed the proposed structures.

Isatine derivativesThiazolidine dioneanti-helmenticanti tubercular
357,800 views
107,498 downloads

Contributors:

 kadapal Gopal
,
 J Savithri,
,
 D. Radha
,
 K. Vijayasantoshalakshmi,
,
 D. Anantha prasad
Research PaperID: AJPTR4160007Pages 110-131

Formulation and Evaluation of Herbal Floating Tablet for The Management of Gastric Ulcer

Ms. Poonam A. Jadhav, Priyanka Sandip Sabale, Sanika Ajit Salvi

Peptic ulcer is a common gastrointestinal disorder characterized by mucosal damage in the stomach or duodenum due to an imbalance between aggressive factors such as gastric acid and protective mucosal defense. Conventional anti-ulcer drugs, although effective, are often associated with high cost and adverse effects. Therefore, the present study aimed to develop and evaluate polyherbal floating tablets as a safer and more effective alternative for gastric ulcer management. The formulation incorporated extracts of Annona squamosa with sodium bicarbonate as a gas-generating agent to enhance buoyancy and prolong gastric retention. Tablets were prepared using the direct compression method by blending plant extracts with suitable polymers and excipients. The prepared formulations were evaluated for physicochemical properties and showed satisfactory results. The floating drug delivery system demonstrated potential for prolonged gastric residence time, which may improve therapeutic efficacy and patient compliance.

Gastric UlcerAnnona squamosaHerbal Floating TabletAnti-ulcer activityGastroretentive drug delivery system
358,413 views
107,527 downloads

Contributors:

 Ms. Poonam A. Jadhav
,
 Priyanka Sandip Sabale
,
 Sanika Ajit Salvi
Research PaperID: AJPTR4160008Pages 132-140

Anti-diabetic and Anti-inflammatory activities of Hydroalcoholic Flower Extract of Sphagneticola trilobata

Dr Gomathi Periyasamy, Emmadi Krupa, Eggadi Sairam, Dandempally Spoorthy, Imran Adil, Deng Aleer Deng Majuch

Diabetes mellitus and inflammation are among the most prevalent chronic disorders worldwide, creating a growing need for safer and more effective therapeutic agents. Medicinal plants have gained significant attention due to their rich phytochemical composition and broad pharmacological activities. The present study aimed to evaluate the in vitro antidiabetic and anti-inflammatory activities of the hydroalcoholic flower extract of Sphagneticola trilobata. Fresh flowers were collected, shade-dried, and extracted using 70% ethanol by the Soxhlet extraction method. The obtained extract showed a percentage yield of 8.24% and was subjected to preliminary phytochemical screening, which confirmed the presence of flavonoids, glycosides, tannins, triterpenes, steroids, carbohydrates, and reducing sugars. The anti-inflammatory activity was assessed by the nitric oxide (NO) inhibition assay using RAW 264.7 macrophage cells, while the antidiabetic activity was evaluated by the glucose utilization assay using HepG2 cell lines, with metformin serving as the standard drug. The extract exhibited dose-dependent anti-inflammatory activity, achieving 69.90% NO inhibition at 100 µg/mL, and demonstrated significant enhancement of glucose utilization, reaching 166.19% of control at 100µg/mL. These findings indicate promising anti-inflammatory and antidiabetic potential, which may be attributed to the synergistic action of the phytoconstituents present in the extract.

Diabetes mellitusInflammationSphagneticola trilobataFlavonoidsNitric oxide inhibitionHepG2 cells+1 more
358,171 views
107,486 downloads

Contributors:

 Dr Gomathi Periyasamy
,
 Emmadi Krupa
,
 Eggadi Sairam
,
 Dandempally Spoorthy
,
 Imran Adil
,
 Deng Aleer Deng Majuch
Research PaperID: AJPTR4160009Pages 141-164

The Herbal Barrier: - Formulation and Evaluation of Lemongrass Based Herbal Mosquito Repellant Cream.

Poonam Ankush Jadhav, Tanvee Uday Shinde, Bhagyashree Sonawane

Mosquito-borne diseases continue to pose a significant public health challenge worldwide, increasing the demand for safe, effective, and environmentally friendly mosquito repellents. The present study aimed to formulate and evaluate a herbal mosquito repellent cream containing extracts of lemongrass (Cymbopogon citratus), neem (Azadirachta indica), tulsi (Ocimum sanctum), and clove (Syzygium aromaticum), which are well known for their insect-repellent and antimicrobial properties. The herbal extracts were incorporated into a cream base using the emulsification method to obtain a stable topical formulation. The prepared cream was evaluated for its organoleptic characteristics, pH, homogeneity, spreadability, viscosity, washability, irritancy, stability, and mosquito repellent activity. The formulation exhibited acceptable physicochemical properties, good stability, and was non-irritant to the skin. The mosquito repellent evaluation demonstrated satisfactory protection against mosquito bites for a considerable duration, indicating the synergistic effect of the selected herbal ingredients. The findings suggest that the developed herbal mosquito repellent cream is a promising natural alternative to synthetic chemical repellents, offering effective protection with improved safety and better skin compatibility. Further studies involving large-scale stability testing and clinical evaluation are recommended to establish its long-term efficacy and commercial potential. Keywords: Herbal mosquito repellent cream, Lemongrass, Neem, Tulsi, Clove, Herbal formulation, Topical cream, Natural insect repellent.

Herbal mosquito repellent creamLemongrassNeemTulsiCloveHerbal formulation+2 more
358,657 views
107,482 downloads

Contributors:

 Poonam Ankush Jadhav
,
 Tanvee Uday Shinde
,
 Bhagyashree Sonawane
Research PaperID: AJPTR4160010Pages 165-179

HERBAL MOSQUITO REPELLENT SPRAY FROM CITRONELLA (CYMBOPOGON) OIL

Poonam A. Jadhav, Ashish Sorte, Rahul Sutar

The present study was conducted to evaluate the mosquito repellent activity of selected plant materials to develop safe and effective herbal mosquito repellent formulations by combining these materials. Seeds of Azadirachta indica were soaked in hexane overnight, and the extract was filtered and concentrated using a rotary evaporator.1) The same procedure was followed for leaves of Vitex negundo using both hexane and ethanol as solvents. Hydro-distillation was carried out using a Clevenger apparatus to obtain essential oils from the leaves of Ocimum sanctum, the rhizomes of Curcuma longa, and the peels of Citrus sinensis. Essential oils of Cymbopogon nardus leaves, Eucalyptus globulus leaves, and Syzygium aromaticum buds were procured from a trusted source. Ethanol solutions containing 10% (v/v) of each extract or essential oil were prepared and tested for mosquito repellent activity using the arm-in-cage method. In this method, a volunteer’s forearm treated with 1 ml of the test solution was exposed to a cage containing 20 blood-seeking mosquitoes, and the number of mosquitoes that landed or attempted to bite the arm was recorded each minute for five minutes. Three replicates were conducted for each sample. After analyzing the repellency of each individual extract. KEY WORDS : Cymbopogon nardus , Ocimum sanctum , Syzygium aromaticum , Curcuma Longa.

Cymbopogon nardusOcimum sanctumSyzygium aromaticumCurcuma Longa.
358,353 views
107,523 downloads

Contributors:

 Poonam A. Jadhav
,
 Ashish Sorte
,
 Rahul Sutar
Research PaperID: AJPTR4160011Pages 178-189

DEVELOPMENT OF ORALLY DISINTEGRATING TABLETS OF TERBINAFINE HYDROCHLORIDE USING NOVEL SUPERDISINTEGRANTS

Dr Reddy Sunil, Bathini Ramgopal Goud, Chikram Vigneshwar

The objective of the present study was to design and optimize fast-dissolving tablets of Terbinafine Hydrochloride using different superdisintegrants to enhance the disintegrating properties of the tablets. Fast-dissolving tablets were prepared using direct compression with help of different super disintegrants such as Kollidon, Vivasol, Tulsion 330, etc., at different concentrations.

oral disintegration tabletshardness testinvitro dissolution time
358,713 views
107,561 downloads

Contributors:

 Dr Reddy Sunil
,
 Bathini Ramgopal Goud
,
 Chikram Vigneshwar

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