Neeraj Kumar

This review provides an in-depth exploration of Cannabidiol (CBD), a substance originating from the Cannabis species with noteworthy therapeutic potential. It comprehensively covers CBD's botanical origins, diverse extraction methodologies, and the emerging significance of nanoformulations in addressing a wide spectrum of health conditions, including pain, inflammation, anxiety, depression, and neurological disorders. The section on botanical origins delves into the sources of CBD within the Cannabis plant, highlighting the chemical variations among different strains and the Biosynthesis of the cannabidiol in cannabis sativa. The historical significance of CBD is elucidated, offering insights into its traditional uses across various cultures and historical contexts. The review paper extensively discusses various extraction techniques employed for CBD isolation, presenting a comparative analysis of their efficacy, safety, and environmental implications. Special attention is devoted to advanced extraction methodologies designed to optimize CBD yield while minimizing the content of psychoactive constituents, such as THC (delta-9-tetrahydrocannabinol). Additionally, this paper emphasizes the burgeoning domain of CBD nanoformulations, elucidating how nanotechnology augments CBD's bioavailability, stability, and targeted delivery. This advancement in drug delivery systems enhances CBD's therapeutic potential in the management of pain, inflammation, anxiety, depression, and neurological disorders. By offering information ranging from CBD's botanical origins to cutting-edge nanoformulations, this review paper is an invaluable resource for researchers, healthcare professionals, and policymakers. This review aims to deliver a succinct overview of the pharmacological, extraction technologies, phytochemical, botanical and ethnopharmacological regarding Cannabidiol. Keywords: Cannabidiol (CBD), Cannabis Sativa, Extraction Methods, Therapeutic effect.

Present study was design to investigated In vitro antioxidant activity of hydroethanolic (HEETF), methanolic (METF) and aqueous extracts (AQETF) of Thalictrum foliolosum family-Ranuculacaece. Traditionally used for jaundice, antimalarial, antipyretic, Diuretics, dyspepsia and febrifuge was found in scientific literature. The antioxidant activity (AA) was determined by the possible four complementary test assay methods namely total phenolic content, total flavonoid content, Inhibition of  2,2 diphenyl -1 picrylhydrazyl (DPPH) radicals and ABTS (2-2’- azinobis) radical scavenging activity or quenching activity .Total phenolic content were found in HEETF, METF and AQETF 43.64±24.2, 53.64± 32.8 and 55.82±30.6 respectively, result shows as mg/GAE/ g of extract. Total flavonoid content  were found in HEETF, METF and AQETF 25.43±31.3, 33.42± 29.3 and 42.67±31.8 respectively, result shows as mg/Rutin /g of extract.  In DPPH radical scavenging activity, IC50 value were found in HEETF, METF and AQETF 4.270µg/ml, 4.90 µg/ml and 5.170 µg/ml respectively, in ABTS 2-2’- azinobis radical scavenging activity value were found in HEETF, METF and AQETF  3.35µg/ml, 3.58µg/ml and  4.86 µg/m respectively. The present study revealed that hydroethanolic extract shows significant Antioxidant, Thus it provides a platform for further research, it could be a potential candidate for further drug development