Wet granulation.

The main objective of the current research work was to formulate and evaluate taste masked effervescent tablet. Dicyclomine HCl is very bitter in taste. The purpose of this research was to reduce the bitterness of Dicyclomine HCl using Hydroxyl Propyl Betacyclodextrin by inclusion complex method and formulate effervescent tablet with sufficient mechanical integrity and to achieve faster disintegration in the water.: Components excipients and Dicyclomine HCl HP- Betacyclodextrin inclusion complex were selected based on preliminary studies. A comparative evaluation of the taste masking was carried out for developed formulation. Citric acid, tartaric acid, sodium bicarbonate was used in 1:2:3.44 ratio for effervescent mixture. 32full factorial design was applied. Ratio of citric acid and hardness were taken as independent variables dissolution of Paracetamol and Dicyclomine HCl at 5 minutes, disintegration time, and friability were taken as dependent variables. Optimized formulation was then evaluated for general tablet evaluation and dissolution. Short term accelerated stability studies were performed for tablets prepared using optimized formulation. Optimized batch composition had ratio of Paracetamol: citric acid and hardness at concentration of 1:0.45 (mg) and 8 (kg/cm2) respectively. All the evaluation parameters of the optimized batch met the acceptance criteria. The taste masked effervescent tablet of Paracetamol and Dicyclomine HCl was formulated successfully by wet granulation method. Keywords: Paracetamol, Dicyclomine HCl, Taste masking, Effervescent tablet, Wet granulation.

The objective of this study is to select between native and treated guar gum as tablet disintegrant and to explore the possible influences of disintegrant content and production method on different tablet attributes using promethazine-HCl as a model drug. Tablet batches were formulated according to 23 full factorial design in which each of the selected factors was investigated at two possible levels for their individual and combined influences on tablets properties. Native and treated gum were considered for guar gum type, guar content was examined at 2 and 8%w/w whereas dry and wet granulation were selected as levels for tablets production method. Guar gum content was demonstrated to affect weight variation, thickness variation and friability properties of different tablet batches (p ranged 0.012-0.038). Guar gum type was also established to influence weight and thickness variation as well as disintegration and drug dissolution properties (p ranged 0.025-0.039). Influences of production method on weight variation, thickness variation, friability, disintegration and drug dissolution properties were found to be considerable (p< 0.05, for all effects). None of the investigated factors has measured a significant effect on tablet hardness property (p ranged 0.4511- 0.9214 for the effects of all factors). Compared to native guar gum, treated guar gum was found to be more efficient as a tablet disintegrant (p= 0.039). Formulations including 2 or 8% w/w treated guar gum and processed by dry granulation were found to yield tablets with average short disintegration time (5.0 ± 0.9 min) and enhanced dissolution efficiency (0.805 ± 0.005).