bioactive compounds

Pergularia daemia (Forssk.) Chiov., commonly known as Veliparuthi or Utranmul, is a perennial climbing herb belonging to the Asclepiadaceae family. This plant has been extensively used in traditional medicinal systems including Ayurveda, Unani, and Siddha for treating various ailments. This comprehensive review synthesizes current knowledge on the ethnobotanical uses, phytochemical composition, and pharmacological properties of P. daemia. The plant contains diverse bioactive compounds including alkaloids, flavonoids, glycosides, saponins, tannins, and steroids. Extensive pharmacological studies have demonstrated multiple therapeutic properties including antidiabetic, anti-inflammatory, antimicrobial, antioxidant, hepatoprotective, anticancer, wound healing, and immunomodulatory activities. This review critically evaluates the scientific evidence supporting traditional uses and discusses the molecular mechanisms underlying the observed pharmacological effects. Despite promising preclinical findings, clinical trials are needed to validate therapeutic efficacy and safety. This review provides a comprehensive foundation for future research aimed at developing evidence-based phytopharmaceuticals from P. daemia.

Plants are widely used by people in traditional and modern medicine all over the world. In fact, all of their remedies can be used safely and without the side effects of drugs. Phytochemical analysis of medicinal plants has revealed that numerous bioactive compounds in plants traditionally used for medicinal purposes have many therapeutically properties. Hence in the present study, a general chemical identification of a Lebanese medicinal plant Urtica dioica was carried out. The results obtained validate the traditional uses of nettle, and showed that this plant possesses an important pharmaceutical value and leads to the isolation and characterization of three compounds from hexane extract. Structures of these compounds were elucidated by spectral methods [FTIR, GC-MS, 1H NMR] after column chromatography on silica gel.