guar gum

Background: Facial cleansers remove excess oil and impurities while maintaining skin comfort. Zinc PCA was selected for its sebum-regulating properties, and kaolin clay was used as an adsorbent. Objective: To formulate and evaluate eight clay-based facial cleansers containing Zinc PCA and kaolin clay using xanthan gum or guar gum as thickening agents. Methods: The formulations (F1–F8) were prepared using a simple mixing method. Zinc PCA (0.5%), kaolin clay (5%), glycerin (10%), disodium EDTA (0.3%), cocamidopropyl betaine (6%), and sodium benzoate (0.5%) were kept constant. Xanthan gum concentrations ranged from 0.2% to 0.5% in F1–F4, while guar gum concentrations ranged from 0.4% to 0.7% in F5–F8. The formulations were evaluated for FTIR compatibility, appearance, homogeneity, pH, viscosity, spreadability, washability, phase separation, and foam height. Results: All formulations appeared milky, cloudy, and off-white, with visual homogeneity. The pH ranged from 5.16 to 5.51, viscosity from 260 to 2100 mPa·s, and foam height from 1.40 to 4.53 cm. Spreadability values ranged from 220.8 to 528.57 g·cm/s. No phase separation was observed in F1–F4, whereas F5–F8 showed separation. F2 and F7 were identified as preferred candidates based on the overall evaluation. Conclusion: Zinc PCA–kaolin clay facial cleansers were successfully formulated. However, guar-gum formulations require further optimization to improve stability. Long-term stability, safety, and efficacy studies are necessary before confirming their skin benefits. Keywords: sebum regulation; skin barrier; adsorbent; xanthan gum; guar gum

The purpose of present work was for formulation and characterization of Clopidrogrel floating tablets to improve bioavailability and to minimize the side effects of the drug. FTIR studies were conducted for drug polymer compatibility. The Clopidrogrel sustained release floating tablets were formulated by wet granulation method.  Tablets were subjected to pre and post compressional evaluation studies. The different concentrations of HPMC K4M, HPMC K15M, xanthan gum, guargum, and sodium bi carbonate 25% w/w is used as gas generating agent and micro cellulose crystalline MCC are used in different concentrations (75%, 50%, 25%) as diluent. The tablets were tested for thickness, weight variation, hardness, friability, drug content; In vitro floating parameters and drug release studies were also conducted. Compatibility studies revealed that there is no interaction between drug and polymers in the formulations. The flow properties were within the limits and the granular bed exhibited uniform flow and ease for compression. Clopidogrel floating tablets showed uniform post compressional properties with minimum standard deviation. The formulations showed minimum floating lag time and prolonged duration of floating. In vitro drug release of clopidogrel was sustained up to 12 h. Clopidrogrel release followed zero order, first order, Higuchi drug release kinetics for drug release. The peppas diffusion coefficient ranged from 0.455 - 0.895 indicating drug release by non fickian diffusion followed by erosion. The F4 floating tablet was optimized formulation which showed 100% release sustained for 12 h. The stability studies indicated stability of drug in the optimized formulation against temperature and humidity.