Skip to main content
editor@ajptr.com
9409046853
e-ISSN: 2249-3387
American Journal of PharmTech Research

American Journal of PharmTech Research

Published

FORMULATION AND EVALUATION OF FACIAL CLAY CLEANSERS BY USING ZINC PCA AND KAOLIN CLAY

Published in October 2026 Issue 5 (Vol. 16, Issue 5, 2026)

FORMULATION AND EVALUATION OF FACIAL CLAY CLEANSERS BY USING ZINC PCA AND KAOLIN CLAY - Issue cover

Abstract

Background: Facial cleansers remove excess oil and impurities while maintaining skin comfort. Zinc PCA was selected for its sebum-regulating properties, and kaolin clay was used as an adsorbent. Objective: To formulate and evaluate eight clay-based facial cleansers containing Zinc PCA and kaolin clay using xanthan gum or guar gum as thickening agents. Methods: The formulations (F1–F8) were prepared using a simple mixing method. Zinc PCA (0.5%), kaolin clay (5%), glycerin (10%), disodium EDTA (0.3%), cocamidopropyl betaine (6%), and sodium benzoate (0.5%) were kept constant. Xanthan gum concentrations ranged from 0.2% to 0.5% in F1–F4, while guar gum concentrations ranged from 0.4% to 0.7% in F5–F8. The formulations were evaluated for FTIR compatibility, appearance, homogeneity, pH, viscosity, spreadability, washability, phase separation, and foam height. Results: All formulations appeared milky, cloudy, and off-white, with visual homogeneity. The pH ranged from 5.16 to 5.51, viscosity from 260 to 2100 mPa·s, and foam height from 1.40 to 4.53 cm. Spreadability values ranged from 220.8 to 528.57 g·cm/s. No phase separation was observed in F1–F4, whereas F5–F8 showed separation. F2 and F7 were identified as preferred candidates based on the overall evaluation. Conclusion: Zinc PCA–kaolin clay facial cleansers were successfully formulated. However, guar-gum formulations require further optimization to improve stability. Long-term stability, safety, and efficacy studies are necessary before confirming their skin benefits. Keywords: sebum regulation; skin barrier; adsorbent; xanthan gum; guar gum

References

  1. [1]Acknowledgements: The original project report acknowledges the guidance and support of the Department of Pharmaceutics, Togari Veeramallappa Memorial College of Pharmacy, Ballari, and assistance with FTIR analysis. Thiboutot MD. Regulation of human sebaceous glands. Journal of investigative dermatology. 2004 Jul 1;123(1):1-2. Sarruf FD, Issa MG, Velasco MV, Rosado C, Baby AR. Clay-Based Cosmetic Formulations: Mineralogical Properties and Short-Term Effects on Sebum Regulation and Skin Biomechanics. Cosmetics. 2025 Oct 4;12(5):219. Mukhopadhyay P. Cleansers and their role in various dermatological disorders. Indian journal of dermatology. 2011 Jan;56(1):2. Wikipedia contributors. Kaolinite [Internet]. Wikipedia, The Free Encyclopedia. Available from: https://en.wikipedia.org/wiki/Kaolinite [Accessed 9 Jul 2026]. Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks Jr JG, Shank RC, Slaga TJ, Snyder PW, Gill LJ. Safety assessment of PCA (2-Pyrrolidone-5-carboxylic acid) and its salts as used in cosmetics. International journal of toxicology. 2019 Sep; 38(2_suppl):5S-11S. Prachi PU, Sanap. AS. Formulation and development of face serum. International journal of creative research thoughts.2023; 11(6):833-845.Adam PG, Mhaske ST. Studies in rheological behaviour of guar gum solution. Macromolecules. 2014;10(1):1–6. Adam PG, Mhaske ST. Studies in rheological behaviour of guar gum solution. Macromolecules. 2014;10(1):1–6. Peric I, Nishimura T. Leveraging synergy between guar and xanthan gums: A modern formulation tool. HPC Today. 2023;18(1):24–29. Yoon SJ, Chu DC, Juneja LR. Chemical and physical properties, safety and application of partially hydrolized guar gum as dietary fiber. Journal of Clinical Biochemistry and Nutrition. 2008;42(1):1–7. Indian Pharmacopoeia Commission. Xanthan Gum. In: Indian Pharmacopoeia. Vol.3. Ghaziabad (India): Indian Pharmacopoeia Commission, Ministry of Health and Family Welfare, Government of India; 2014. p. 2995–2997. Asirvatham E, inventor; Advansix Resins, Chemicals LLC, assignee. Surfactants for personal care and cosmetic products. United States patent application US 17/196,886. 2021 Sep 16. Schelges H, Scholz E, inventors; Henkel AG and Co KGaA, assignee. Natural cosmetic cleanser which is solid at room temperature. United States patent application US 16/659,958. 2020 Jun 11. Sans A, Candolives M, Hauchecorne S, inventors. Mild, foaming cleansing composition. United States patent application US 12/056,616. 2009 Feb 5. Barel AO, Paye M, Maibach HI, editors. Handbook of cosmetic science and technology. CRC press; 2014 Apr 9. Tadros TF. Rheology of dispersions: principles and applications. John Wiley & Sons; 2011 Jul 18. Barel AO, Paye M, Maibach HI, editors. Handbook of cosmetic science and technology. CRC press; 2014 Apr 9. Tadros TF. Rheology of dispersions: principles and applications. John Wiley & Sons; 2011 Jul 18.. L'Oréal. Low viscosity emulsion cosmetic composition. US Patent 12,036,304. 2024 Jul 16. Fiume MM, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks Jr JG, Shank RC, Slaga TJ, Snyder PW. Safety assessment of microbial polysaccharide gums as used in cosmetics. International journal of toxicology. 2016 Jul;35(1_suppl):5S-49S. Burnett CL, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks Jr JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Final report of the Cosmetic Ingredient Review Expert Panel on the safety assessment of cocamidopropyl betaine (CAPB). International journal of toxicology. 2012 Aug;31(4_suppl):77S-111S. Johnson Jr W, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks Jr JG, Shank RC, Slaga TJ, Snyder PW. Safety assessment of galactomannans as used in cosmetics. International journal of toxicology. 2015 Jul;34(1_suppl):35S-65S. Eloystina LJ, Aldila S, Girsang V, Sa'adah A. An Irritation Test of Optimum Preparation of Celery Extract Face Clay Cleanser With Sodium Lauryl Sulfate (SLS) and Cocamidopropyl Betaine (CAPB) as Surfactants: Irritation Test of Optimum Preparation of Celery Extract Face Clay Cleanser With Sodium Lauryl Sulfate (SLS) and Cocamidopropyl Betaine (CAPB) as Surfactants. Science and Community Pharmacy Journal. Vandkar A, Shaikh R, Thombare R, Chivate A, Chivate N. Formulation and Analysis of Herbal Face Wash Using Luffa Cylindrica Seeds Oil Extract as a Soap Base.

Authors (6)

G Govinda Reddy

Togari Veeramallappa Memorial ...

View all publications →

Karthik K A

Department of Pharmaceutics, T...

View all publications →

Chaithanya Jeer

Department of Pharmaceutics, T...

View all publications →

Chitrakala

Department of Pharmaceutics, T...

View all publications →

D Madhu Sree

Department of Pharmaceutics, T...

View all publications →

B Santhosh Kumar

Department of Pharmaceutics, T...

View all publications →

Download Article

PDF

Best for printing and citation

File size: 0.7 MB
Format: PDF

Summarise this paper with AI:

Article Information

AJPTR5160015

AJPTR-02-002521

232-254

2026-11-02

JATS XML

Article Impact

Views:3,085
Downloads:2,148

How to Cite

Govinda Reddy, G., A, K. K., Jeer, C., Chitrakala, Madhu Sree, D., & Santhosh Kumar, B. (2026). FORMULATION AND EVALUATION OF FACIAL CLAY CLEANSERS BY USING ZINC PCA AND KAOLIN CLAY. American Journal of PharmTech Research, 16(5), 232-254. https://ajptr.com/articles/AJPTR5160015

Article Actions

Whatsapp