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DESIGN AND EVALUATION OF CLINDAMYCIN HYDROCHLORIDE PRONIOSOMAL GEL FOR TOPICAL DELIVERY

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Published in October 2026 Issue 5 (Vol. 16, Issue 5, 2026)

DESIGN AND EVALUATION OF CLINDAMYCIN HYDROCHLORIDE PRONIOSOMAL GEL FOR TOPICAL DELIVERY - Issue cover

Keywords

ProniosomesClindamycin hydrochlorideCo-acervation phase separationTopical gelIn vitro drug releaseRelease kinetics.

Abstract

The present study aimed to formulate and evaluate Clindamycin hydrochloride-loaded proniosomal gel for topical drug delivery with improved entrapment efficiency, controlled release, antimicrobial activity, and skin tolerability. The formulations were evaluated for preformulation properties, drug–excipient compatibility, entrapment efficiency, particle size, zeta potential, SEM, physicochemical properties, in-vitro drug release, release kinetics, antimicrobial activity, skin irritation, and stability. UV spectrophotometric analysis showed maximum absorption at 210 nm, with good linearity over 2–10 µg/ml (R² = 0.9992). FTIR studies indicated no significant incompatibility between Clindamycin hydrochloride and the selected excipients (Span 60, cholesterol, and soya lecithin). Among the prepared formulations, F6 was selected as the optimized formulation. It exhibited an entrapment efficiency of 86.7 ± 0.3%, particle size of 249.69 nm, PDI of 0.362, and zeta potential of 35.7 mV. SEM revealed discrete, approximately spherical vesicles. The optimized gel showed a pH of 6.45 ± 0.03, spreadability of 28.9 ± 0.05 g·cm/sec, viscosity of 8890 cps, and drug content of 85.7 ± 0.3%. In-vitro drug release reached 86.34% at 7 hours, following first-order kinetics (R² = 0.9901). The formulation demonstrated antimicrobial activity and caused no visible erythema or edema. Additionally, only minor changes in entrapment efficiency were observed during the four-week stability study. Overall, F6 demonstrated promising physicochemical properties, controlled drug release, antimicrobial activity, and topical tolerability.

References

  1. [1]Barati N, Loona S, Khan MMU. Proniosomes: a recent advancement in nanotechnology as a drug carrier. Int J Pharm Sci Rev Res. 2012;12(1):67-75.
  2. [2]2. Jadhav RK, Ashish YP, Ashwini AB, Sathish AA. Proniosomes: a novel non-ionic provesicular carrier as potential drug carrier. Asian J Pharm. 2016;10(3):210-20.
  3. [3]3. Sundhamani T, Priyadarisini N, Radhakrishnan M. Proniosomes – a promising drug carrier. Int J PharmTech Res. 2010;2:1446-54.
  4. [4]4. Hemanth NP, Sharwaree RH, Ashok VB. Formulation, development and evaluation of gel of carvedilol. Int J Pharm Sci. 2012;4(1):191-4.
  5. [5]5. Spizek J, Rezanka T. Lincosamides: chemical structure, biosynthesis, mechanism of action, resistance, and applications. Biochem Pharmacol. 2017;133:20-8.
  6. [6]6. Leclercq R, Courvalin P. Bacterial resistance to macrolide, lincosamide, and streptogramin antibiotics by target modification. Antimicrob Agents Chemother. 1991;35(7):1267-72.
  7. [7]7. Ita K. Transdermal drug delivery: progress and challenges. J Drug Deliv Sci Technol. 2014;24:245-50.
  8. [8]8. Karnool AN. Proniosomes: innovative vesicular drug delivery system – a review. Int J Pharm Sci Rev Res. 2019;59(2):44-51.
  9. [9]9. Vilegave K, Vidyasagar G, Chandankar P. Preformulation studies of pharmaceutical new drug molecule and products: an overview. Am J Pharm Health Res. 2013;1(3):1-20.
  10. [10]10. European Pharmacopoeia. Phosphate buffer solution pH 7.4 [monograph 4.1.3]. Available from: drugfuture.com/Pharmacopoeia/EP7.
  11. [11]11. Pankaj S, Rini T, Dandagi PM. Formulation and evaluation of proniosomes-based drug delivery system of the antifungal drug clotrimazole. Int J Pharm Sci Nanotechnol. 2013;6(1):1945-51.
  12. [12]12. Sharma BS, Bhogale V, Adepu AR, Patil ST, Sangu SK. Proniosomes: a novel provesicular drug delivery system. Int J Pharm Res. 2015;4(1):105-19.
  13. [13]13. Shwetha V, Sunil KB, Sathish S. Formulation and evaluation of proniosomal gel of diclofenac sodium using 3² factorial design. Int J Biopharm. 2015;6(1):48-54.
  14. [14]14. Baig RP, Wais M. Formulation and development of proniosomal gel for topical delivery of amphotericin B. Int J Pharm Pharm Sci. 2022;14:37-49.
  15. [15]15. Sambhakara S, Paliwal S, Sharma S, Singh B. Formulation of risperidone-loaded proniosomes for effective transdermal delivery. Bull Fac Pharm Cairo Univ. 2017;55:239-47.
  16. [16]16. Raj Kumar D, Mithun B, Niraj U, Dubey BK. Design and evaluation of proniosomes as a drug carrier for ocular delivery of levofloxacin. J Drug Deliv Ther. 2014;4(5):182-9.
  17. [17]17. Guptha A, Prajapathi SK, Balamurugan M, Singh M, Bhatia D. Design and development of proniosomal transdermal drug delivery system of captopril. Trop J Pharm Res. 2011;10(2):687-93.
  18. [18]18. Hossain TJ. Methods for screening and evaluation of antimicrobial activity: a review of protocols, advantages, and limitations. Eur J Microbiol Immunol. 2024;14(2):97-115.
  19. [19]19. Yadav V, Jadhav P, Dombe S, Bodhe A, Salunkhe P. Formulation and evaluation of microsponge gel for topical delivery of an antifungal drug. Int J Appl Pharm. 2017;9:30-7.
  20. [20]20. Harwood RJ, Cohen EM. Solubility of cholesterol in isopropyl myristate. J Soc Cosmet Chem. 1977;28:79-82.
  21. [21]21. Schneider M. Achieving purer lecithin. Drug Cosmet Ind. 1992;150(2):54-103.
  22. [22]22. DrugBank. Clindamycin – pharmacology. Available from: go.drugbank.com/drugs/DB01190.

Authors (2)

Vijay Kengari

Shree Devi college of pharmacy

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V. Felix Joe

Shree Devi college of pharmacy

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Article Information

Published in:

October 2026 Issue 5 (Vol. 16, Issue 5, 2026)

AJPTR5160019

AJPTR-02-002525

309-323

2026-11-05

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How to Cite

Kengari, V., & Felix Joe, V. (2026). DESIGN AND EVALUATION OF CLINDAMYCIN HYDROCHLORIDE PRONIOSOMAL GEL FOR TOPICAL DELIVERY. American Journal of PharmTech Research, 16(5), 309-323. https://ajptr.com/articles/AJPTR5160019

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