Annona squamosa

Peptic ulcer is a common gastrointestinal disorder characterized by mucosal damage in the stomach or duodenum due to an imbalance between aggressive factors such as gastric acid and protective mucosal defense. Conventional anti-ulcer drugs, although effective, are often associated with high cost and adverse effects. Therefore, the present study aimed to develop and evaluate polyherbal floating tablets as a safer and more effective alternative for gastric ulcer management. The formulation incorporated extracts of Annona squamosa with sodium bicarbonate as a gas-generating agent to enhance buoyancy and prolong gastric retention. Tablets were prepared using the direct compression method by blending plant extracts with suitable polymers and excipients. The prepared formulations were evaluated for physicochemical properties and showed satisfactory results. The floating drug delivery system demonstrated potential for prolonged gastric residence time, which may improve therapeutic efficacy and patient compliance.

In the present paper an effort was made to isolate a biomaterial from the fruit pulp of Annona squamosa and evaluate its film forming capacity. Annona squamosa was isolated by an economic method and subjected to various physical evaluation parameters. The biomaterial was subjected to spectral studies like IR, 1H NMR and DSC analyses. Phenytoin loaded biofilms were prepared using the isolated biomaterial and other co- processing agents. The prepared biofilms were evaluated for their film parameters and subjected to in-vitro drug release studies using static MS diffusion apparatus. The results were compared with the standard HPMC film. The experimental results revealed that the prepared biofilms possessed good folding endurance with appreciable release characteristics. The best film formulation was PS6 with percentage cumulative release of 91.85% over 36 hours. Hence it clearly indicated that the isolated biomaterial possessed inbuilt filmability.

  Medicinal plants play a vital role to preserve human health. Herbs valued for centuries as a traditional medicine, has been used to treat various human ailments. The leaves of Coleus aromaticus are useful in cephalagia, otalgia, anorexia, dyspepsia, flatulence, colic, diarrhoea, cholera, halitosis, convulsions, epilepsy, cough, asthma, hiccough, bronchitis, strangury, hepatopathy and malarial fever. Annona squamosa Linn is used as an antioxidant, antidiabetics, hepatoprotective, cytotoxicactivity, genetoxicity, antitumor activity, antilice agent. We report here the effects of various plants extracts on the cell viability. The cell viability assay revealed that the aqueous extract of Coleus aromaticus leaves and methanolic extract of Annona squamosa leaves showed significant results. Further phytochemicals screening of the extracts of both the plants revealed presence of Flavonoids on the above extracts. The total flavonoids content were determined by aluminum chloride colorimetric method. The total flavonoids contents of aqueous extract Coleus aromaticus & methanolic extracts of Annona squamosa leaves were found to be 2.60% and 2.4% respectively. Key words: Coleus aromaticus, Annona squamosa,Cell viability , Spectrophotometric.