In-Vitro Anthelmintic Activity of Mollugo Nudicaulis Lam, Syzygium Cumini Linn And Hibiscus Vitifolius Linn On Pheretima Posthuma
Carolin Nimila.I1*, Ajith kumar.B1, Sudha.N1, Priya.P1, Sambath kumar.R1
1. Department of Pharmaceutical Analysis, J.K.K.Nattraja College of Pharmacy, Kumarapalayam, Namakkal, Tamil Nadu, India.
The present paper investigated the In-vitro anthelmintic activity of ethanolic extracts of Mollugo nudicaulis Lam, Syzygium cumini Linn and Hibiscus vitifolius Linn to determine the possible effects by using Pheretima Posthuma (Indian adult earthworm). Two concentrations of each extracts (50,100mg/ml) were used in this activity and the same concentration of Albendazole as a standard drug and distilled water with 1%w/v carboxyl methyl cellulose as control. Determination of paralysis time (vermifuge) and death time (vermicidal) of the worms were noted. It was found that the ethanolic extracts of three plants exhibited significant anthelmintic activity at a concentration of 100mg/ml of MNE (highest activity) followed by SCE and HVE (least activity). The above traditional plants confirms the presence of ethanobotanical uses. The plants may be further explored for isolation of active constituents to bring a new active lead for suitable anthelmintic activity.
Keywords: Mollugo nudicaulis Lam, Syzygium cumini Linn, Hibiscus vitifolius Linn, Anthelmintic activity, Albendazole, Vermifuge, Vermicidal.