ABSTRACT

Drug information service provides accurate, relevant and unbiased information on drugs and any aspects related to drugs. The objective of this study was to conduct the quality assurance of drug information service provided. The study was conducted for a period of six months in the drug information centre of a tertiary care hospital in Calicut. Quality assurance was done on the basis of modified systematic approach. A total of 45 drug information queries were received in the drug information center during the study period. Among the queries majority were from pharmacy (77.78%) and nursing station (22.22%). A checklist on basis of modified systematic approach was used to verify the quality. In the queries collected 85% enquirer’s details was relevant enough and 15% were incomplete. Drug information response had a professional style in 70% and whereas 30% were not having standard presentation such as alignment or spacing, etc. Among the 20 of the drug information collected for evaluation 90% had relevant information for the query and remaining 10% needed more details. In the source of references given in the response 60% were partial and 40% were incomplete. Based on the time taken for response 55% was timely given and 45% took more time than it really required. The documentation procedure was complete and perfect in all case. Study concluded that although drug information service is actively performed the quality of service has to be upgraded. Standard operating procedure has to be framed and revised as per the lacunas found.

Keywords: Quality Assurance, Drug Information Service.

ABSTRACT

In the current investigation we formulated and evaluates matrix tablet using modified gum of Pistacia lantiscus gum (PLMG) as natural matrix forming agent used in various successively increasing concentration. The pre-compression study of the powder blends of drug, PLMG and other excipients were done by calculating bulk density, tapped density, angle of repose and carr’s index (% compressibility) and hausner’s ratio. The tablets using PLMG as matrix forming agent were prepared by direct compression method and prepared tablets were evaluated for thickness, hardness, weight uniformity, friability and content uniformity and were found according to the official guidelines by pharmacopoeia. The swelling behavior of prepared matrix tablets was studied using for 12 hours at 37 ±0.2 ⁰C, it was fond that the drug to modified gum ratio of 1:2 was found to be optimum swelling with the sustained release of model drug up to 97.12 in matrix tablet formulation. The results revealed, that modified fraction of Pistacia lantiscus gum can be used as a drug release modifier to delay as the rate of drug release of which depended on the amount of gum composition, as the concentration of gum was increased there was sustain the drug release.

Keywords: Pistacia lantiscus, tablet, modified gum, diclofenac potassium, hausner’s ratio.

ABSTRACT

Peptic ulcer is a common gastrointestinal disease seen among many peoples. It may be caused by irregular food habits, spicy foods, either an infection or long-time use of medications, drugs and stress. An ulcer depends upon the presence of acid and peptic activity in gastric juice plus a breakdown in mucosal defences. A number of anti-ulcer drug are available for curing ulcer disease. Standard treatment is including antibiotics and proton pump inhibitors. But the same time these drugs are expensive and there are many side effects caused by these drugs comparing to other herbal medicines. Pantoprazole is an irreversible proton pump inhibitor (PPI) that reduces gastric acid secretion. It is used to treat stomach ulcers, gastro-oesophageal reflux disease (GORD), acid reflux, and heartburn. Zollinger-Ellison syndrome is a rare disorder brought on by a pancreatic or intestinal tumour that is treated with pantoprazole. Both a generic and a brand-name version of the oral tablet medication pantoprazole are offered. A stomach H+/K+-ATPase (hydrogen-potassium adenosine triphosphatase) inhibitor is pantoprazole. Although oral dose forms are the most common drug, they nevertheless have significant drawbacks compared to other delivery systems, such as the possibility of medication absorption that is too sluggish and complicated by gastric residence time. It can be treated by using a lesser dosage of the medication instead of taking it in liquid form. Another technique is the effervescent technique, which can be used to create a dosage form that can speed up the time the drug dissolves and combines with the body. This technique is typically employed with preparations for rapid release. Effervescent tablets are being used more frequently and widely to modify the behaviour of drug release, such as in sustained and controlled release preparations, pulsatilla drug delivery systems, and so forth, along with the development of novel pharmaceutical techniques. The present review illustrated about the etiology of peptic ulcer, its complications, pharmacological property of pantoprazole antiulcer drug and the new effervescent tablet methodology.

Keywords: Peptic ulcer; Pantoprazole; Proton pump inhibitor; Floating Delivery System; Effervescent Tablet

ABSTRACT

The Piper chaba ethanolic extract showed protection against characteristic lesions produced by ulcer due to Indomethacin administration. This gastroprotective effect of Piper chaba ethanolic extract may be due to both reductions in gastric acid secretion and gastric cytoprotection which may further contribute in the treatment of peptic ulcers. Indomethacin produces necrotic lesions in the gastric mucosa by reducing the secretion of bicarbonate and production of mucus, increasing vascular permeability and decreasing non-protein sulfhydryl groups of gastric mucosa. Indomethacin rapidly penetrates the gastric mucosa apparently causing cell and plasma membrane damage leading to increased intracellular membrane permeability to sodium and water and thus causing gastric mucosa damage. Suppression of prostaglandins synthesis by ethanol results in increase susceptibility of the stomach to mucosal injury and gastro duodenal ulceration. The Piper chaba ethanolic extract significantly reduced ulcer index. The Piper chaba ethanolic extract showed protection against characteristic lesions produced by ulcer due to Indomethacin administration. This gastroprotective effect of Piper chaba ethanolic extract may be due to both reductions in gastric acid secretion and gastric cytoprotection which may further contribute in the treatment of peptic ulcers.

Keywords: Antiulcer, Indomethacin, Wistar Rats, Piper Chaba, Ethanolic Extract.

ABSTRACT

An open, before and post without control, interventional clinical trial was used to conduct the investigation. The length of the study was set at 30 days. Nuskha Maulusool was administered in decoction form once per morning (empty stomach) for 15 days to thirty qualified patients with hemiplegia brought on by a stroke. On the 13^th and 15^th days, Nuskha Mushile Balgham was combined with Maulusool and administered orally to induce purgation. Inkebab was introduced with 20 gms of marzanjosh on the 16^th day and continued every day until the study's conclusion. To evaluate the individuals' activities of daily living (ADL), the before and post treatment values of the Barthel index were compared using a paired t test. After receiving treatment, patients' ADL significantly improved (p 0.001). Throughout and after the research, no unpleasant side effects were noticed in the treatment group, and overall treatment compliance was satisfactory. The study found that the test medication improved patients' ADLs in a statistically meaningful way.

Keywords: Unani Medicine; Hemiplegia; ADL; Inkebab; Falije Nisfi; Munzij Mushil