ABSTRACT

As an emerging drug carrier, hydrogels have been widely used for tumour drug delivery. A hydrogel drug carrier can cause less severe side effects than systemic chemotherapy and can achieve sustained delivery of a drug at tumour sites. In addition, hydrogels have excellent biocompatibility and biodegradability and lower toxicity than nanoparticle carriers. Smart hydrogels can respond to stimuli in the environment (e.g., heat, pH, light, and ultrasound), enabling in situ gelation and controlled drug release, which greatly enhance the convenience and efficiency of drug delivery. Here, we summarize the different sizes of hydrogels used for cancer treatment and their related delivery routes, discuss the design strategies for stimuli-responsive hydrogels, and review the research concerning smart hydrogels reported in the past few years

Keywords: Hydrogels, tumour drug delivery system, stimuli responsive materials, biocompatability and biodegradability.

ABSTRACT

To find out the medicinal contribution to the local population of the plants colonizing the mountains of the town of Man, we traveled 5 mountains and interviewed 129 people from the said town. The chosen mountains are called: Kôh mountain, Mount Zélé, Glaha mountain, Glèhè mountain and Gôhô mountain. These mountains were chosen for their significant plant diversity. Plots made at an altitude of 300 to 400 meters were used to inventory the plants. Two indices were used to evaluate the ethnobotanical data, namely the frequency of citation of species (FC) and the relative exploitation level of these plants (NER). The study made it possible to inventory 48 plant species divided into 44 genera and 26 families. The Fabaceae family is the most represented. Ethnomedic investigations revealed the use of these plants in the treatment of 25 common pathologies. The leaves are the organs most used in these treatments. And the technique for preparing drugs is decoction. The ethnobotanical indices evaluated indicated that the species best exploited by the population are Alchornea cordifolia and Euphorbia hirta with a NER = 55% each. These indices also reveal that Chromolaena odorata (FR = 19.58%) and Tithonia diversifolia (FR = 13.23%) are the most common species found at low altitude in the Man Mountains. The results of this work could stimulate further in-depth studies on mountain plants in the search for effective phytomedicines.

Keywords: Ethnobotany, Medicinal plants, Mountains, Man, Côte d’Ivoire

ABSTRACT

In recent years, it has been found that fungal infections in humans have risen. Along with its growth rate, the kind of fungal species also increased considerably. An effective formulation is necessary to treat these fungal infections in a simple manner. The main aim of my research project was to develop a formulation of a topical antifungal Cream. The formulation and development of tropical antifungal formulation have seen great results in the treatment of fungal infections. Over the conventional dosage forms, these topical drug delivery formulations have more benefits along with their extraordinary advantages. This cream formulation consists of natural as well as synthetic ingredients like; Azadirachta Indica, Ocimum sanctum Linn, Liquid paraffin, Stearic acid, Bees wax, Stearyl alcohol Glycerin Tween-80 Methyl parabens Sorbitol solution Potassium hydroxide. ingredients which have antifungal and antibacterial properties.

Keywords: Fungal infection, Topical Antifungal. Azadirachta Indica, Ocimum sanctum Linn, Liquid paraffin, Stearic acid, Bees wax, Stearyl alcohol Glycerin Tween-80 Methyl parabens Sorbitol solution Potassium hydroxide.

ABSTRACT

In the pharmaceutical industry, the Change Control process typically occurs when any change is proposed or required to a product, process, equipment, or system that could potentially affect the quality, safety, or compliance of the product. This paper includes a study to ensure the quality and safety of drugs and also avoids the future risks. This research investigates the root causes of incidents within the change control process in the pharmaceutical industry, analyzing the patterns and trends that lead to non-conformances and quality deviations. It ensures that any modifications, whether planned or unplanned, are thoroughly evaluated, authorized and executed in a controlled manner to minimize disruption, risk and inefficiencies. Changes may occur at any time during the product life cycle, leading to changes in the manufacturing process, the number of materials, and  the manufacturing Location . An effective change control process is critical in the pharmaceutical industry to ensure ongoing compliance with regulatory standards, maintain product quality, and safeguard patient safety, while minimizing potential risks associated with any changes to processes, materials, or systems.

Keywords: Change, Control, Quality, Safety, Process, Compliance, Product, Materials, Regulatory.