ABSTRACT

Artesunate (1) (ART), also called as dihydroartemisinin-12-α-succinate, it is a semisynthetic peroxide-bridged sesquiterpene lactone compound derived from Artemisinin, the bioactive component of the Chinese medicinal herb called Artemisia annua.  An accurate, simple and precise HPLC method was developed and validated for forced degradation studies of drug Artesunate .The column was used C18 column (150X4.6mmX5µm ) column  by isocratic elution. The mobile phase composition consisted of Acetonitrile Water and trifluoroacetic acid (TFA) in the ratio of 55:45:0.1 v/v. The analysis was performed at a 1ml/min flow rate. The analytical performance parameters such as linearity, precision, accuracy, specificity, limit of detection (LOD) and lower limit of quantification (LOQ) were determined according to International Conference for Harmonization ICH Q2 (R1) guidelines.

Keywords: Artesunate, HPLC, Stability, Malaria, Validation

ABSTRACT

Neuropathic pain is intense in nature and difficult to maintain. The main aim of this study is to provide maximum relief from pain.  The objective was to prepare bilayer tablet comprising  of pregabalin and methylcobalamin for effective treatment of neuropathic pain. Methylcobalamin was formulated as immediate release (IR) layer using super-disintegrant sodium starch glycolate (SSG) whereas pregabalin was formulated as sustained release (SR) layer using polymers hydroxypropyl methyl cellulose (HPMCK4M, K100M)  to deliver the drug at sustained manner effective for the treatment of neuropathic pain. The SR layer of pregabalin is prepared by wet granulation method and IR layer of methylcobalamin is prepared by direct compression method. Tablet blends were evaluated through various pre-compression and post-compression tests. Super disintegrant, SSG at 20% concentration produced excellent results for immediate release of methylcobalamin to exert its action and other additional beneficial effects. The K100M and K4M grade of HPMC produced excellent SR efficiency. Optimum formulation released methylcobalamin and pregabalin at 98.92%  in 45 min and 97.81% in 12 h from respective layers. Pre-compression and post-compression parameters of optimized IR layer comprising Methylcobalamin and SR layer comprising pregabalin exhibit satisfactory results. Bilayer tablet of Methylcobalamin and pregabalin prove to be effective as a combination therapy for the treatment of neuropathic pain by sequential release of the drug.

Keywords: Pregabalin,Methylcobalamin,bilayer tablet,hydroxypropyl methyl cellulose,sodium starch glycolate, superdisintegrant.

ABSTRACT

Herbal cream have various studies have been done to assess the antiseptic potential of Blumea Lacera and Turmeric. Blumea Lacera have Activity of antiseptic and antioxidant. Antiseptic a substance that Prevents or arrests the growth or action of micro-organisms either by inhibiting their activity or by destroying them. For all above problem ayurvedic has a fast acting solution in a form of cream which has herbal medicines with antiseptic potential. Another traditional use minor burns and cuts. This cream is not only useful in antiseptic but also to normalize skin colour by erasing scars naturally. The prepared formulations were evaluated based on number criteria including, physical parameters, PH test, wash ability test, phase separation test.

Keywords: Antiseptic, Blumea Lacera, Herbal Cream, Semisolid Dosage form.

ABSTRACT

One significant systemic ailment is chronic renal disease. Co-morbid illnesses combined with declining renal function cause patients to take more than one medication. Choosing the right medications is essential to preventing side effects. This study has a prospective observational design in which all patients with chronic kidney disease (CKD) are included in the analysis. Relevant data was acquired through the use of patient data collection forms, which were filled out and examined. In this study, 120 patients who had prescriptions for medications were reviewed prospectively; of these, 76 (63.33%) were men and 44 (36.66%) were women. According to demographic data, men are more likely to develop CKD. According to demographic information, patients between the ages of 41 and 60 were found to be high in 62 middle-aged individuals (51.66%) and low in young adults (7.83%) in the 19–30 age group. Anti-hypertensive medications were the most commonly prescribed class of pharmaceuticals, followed by cardiovascular, hematinic, and anti-diabetic medications. A total of 1.16% of prescriptions were written under their generic names. 10.96% of prescriptions included an injectable products. Antibiotic prescriptions made up 54.16% of all prescriptions. Ninety-three percent of the medications prescribed came from the WHO Essential medicines list. The study shows that the prescription of brand-name medications was frequently noticed using WHO core indicators, which were used to monitor the drug prescribing trend. This study concludes that CKD patients were more likely to be treated with diuretics, antihypertensives, oral hypoglycemic medications, and hematinic agents.

Keywords: CKD, prescribing patterns, antihyperetensives, hypoglycemic, prevalence, Polypharmacy

ABSTRACT

A class of polymeric materials known as hydrogel products have a hydrophilic structure that allows them to store enormous amounts of water in their three-dimensional networks. More than any other form of synthetic biomaterial, they most nearly resemble genuine living tissue because of their high water content, porosity, and soft consistency. Hydrogels may also be prepared into a wide range of physical forms, such as coatings, films, microparticles, and slabs. Hydrogels are so often utilized in clinical practice and medicine for a variety of purposes, such as cellular immobilization, tissue engineering and regenerative medicine, diagnostics, separation of biomolecules or cells, and barrier materials to control biological adhesions. This biomaterial has the capacity to expand and store huge volumes of biological fluids. They are mushy when swollen.

Keywords: Hydrogel; cross-linking; polymer; hydrogel properties